CHKA, choline kinase alpha, 1119

N. diseases: 64; N. variants: 3
Disease: Mammary Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.040 AlteredExpression group BEFREE Near infrared fluorescent imaging of choline kinase alpha expression and inhibition in breast tumors. 28157707 2017
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.040 AlteredExpression group BEFREE In proof-of-principle studies, we synthesized a nanoplex carrying magnetic resonance imaging (MRI) reporters for in vivo detection and optical reporters for microscopy to image the delivery of siRNA and a functional prodrug enzyme in breast tumors and achieve image-guided molecular targeted cancer therapy. siRNA targeting of choline kinase-α (Chk-α), an enzyme significantly up-regulated in aggressive breast cancer cells, was combined with the prodrug enzyme bacterial cytosine deaminase (bCD) that converts the nontoxic prodrug 5-fluorocytosine (5-FC) to cytotoxic 5-fluorouracil (5-FU). 20958072 2010
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.040 Biomarker group BEFREE These results demonstrate that ChoK plays an essential role in both normal human mammary epithelial cell proliferation and breast tumor progression. 15374991 2004
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.040 Biomarker group LHGDN Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy. 12082619 2002