Disease: Sepsis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0243026
Disease: Sepsis
Sepsis 		0.050 GeneticVariation disease BEFREE Hub genes with high degrees, including interleukin 1 receptor‑associated kinase 3 (IRAK3), S100 calcium‑binding protein (S100)A8, angiotensin II receptor‑associated protein (AGTRAP) and S100A9, were demonstrated to be associated sepsis. 29257295 2018
CUI: C0243026
Disease: Sepsis
Sepsis 		0.050 AlteredExpression disease BEFREE Interleukin-1 receptor-associated kinase 3 downregulation in peripheral blood mononuclear cells attenuates immunosuppression in sepsis. 29434744 2018
CUI: C0243026
Disease: Sepsis
Sepsis 		0.050 GeneticVariation disease BEFREE The aim of this study was to explore the association between the single-nucleotide polymorphisms of interleukin-1 receptor-associated kinase-M (IRAK-M) gene and the susceptibility of sepsis. 23588345 2013
CUI: C0243026
Disease: Sepsis
Sepsis 		0.050 GeneticVariation disease BEFREE Whereas IRAK3 SNPs were not associated with susceptibility to severe sepsis, rs10506481 showed a significant association with the development of ALI among patients with sepsis (P = 0.007). 21297081 2011
CUI: C0243026
Disease: Sepsis
Sepsis 		0.050 Biomarker disease BEFREE IRAK-3 is a negative regulator of Toll-dependant signaling and its induction may impair innate immunity and hence result in an immunocompromised state allowing bacterial survival and systemic spread during sepsis. 21811575 2011