|
Collecting Duct Carcinoma of the Kidney
|
0.300 |
Biomarker
|
disease |
CTD_human |
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma.
|
22138691 |
2011 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma.
|
22138691 |
2011 |
|
Coronary Artery Disease
|
0.110 |
Biomarker
|
disease |
BEFREE |
In contrast, three hub genes including PLEKHG5 (T2D: OR=1, P=1; CAD: OR=1.12, P=0.006), TIAM1 (T2D: OR=1, P=1; CAD: OR=1.48, P=0.004) and AKAP13 (T2D: OR=1, P=1; CAD: OR=1.38, P=0.001) were hub genes unique to CAD.
|
24508273 |
2014 |
|
Coronary Artery Disease
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
|
29212778 |
2018 |
|
Crohn Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
We have now established the PsiNCF1 to NCF1 ratio for a significant number of IBD patients (n = 488) and control subjects (n = 181) and show that there is no statistically significant difference between the frequency of the 1:1 ratio in CD (11.2%) or UC (12.2%) patients and controls (13.4%).
|
15626894 |
2004 |
|
Diabetes
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ASE reduced oxidative damage markers (TBARS, carbonyl levels and 8-isoprostane) in D and DH associated with a decrease in Nox 4 and p47 subunit expression and increase in antioxidant enzyme activity in both groups (SOD, catalase and GPx).
|
28105508 |
2018 |
|
Diabetes Mellitus
|
0.010 |
AlteredExpression
|
group |
BEFREE |
ASE reduced oxidative damage markers (TBARS, carbonyl levels and 8-isoprostane) in D and DH associated with a decrease in Nox 4 and p47 subunit expression and increase in antioxidant enzyme activity in both groups (SOD, catalase and GPx).
|
28105508 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
In contrast, three hub genes including PLEKHG5 (T2D: OR=1, P=1; CAD: OR=1.12, P=0.006), TIAM1 (T2D: OR=1, P=1; CAD: OR=1.48, P=0.004) and AKAP13 (T2D: OR=1, P=1; CAD: OR=1.38, P=0.001) were hub genes unique to CAD.
|
24508273 |
2014 |
|
Endometriosis
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Expression of the proto-oncoprotein breast cancer nuclear receptor auxiliary factor (Brx) is altered in eutopic endometrium of women with endometriosis.
|
16412732 |
2006 |
|
Esophageal Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Discovery of deregulation of zinc homeostasis and its associated genes in esophageal squamous cell carcinoma using cDNA microarray.
|
17068819 |
2007 |
|
Fibroid Tumor
|
0.010 |
Biomarker
|
disease |
BEFREE |
Because AKAP13 augmented nuclear receptor signaling in other tissues, we sought to determine whether AKAP13 might influence PR signaling in fibroids.
|
30239831 |
2019 |
|
Finding of Mean Corpuscular Hemoglobin
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Fuchs Endothelial Dystrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Three genes (MBNL1, KIF13A, AKAP13) that were previously identified as misspliced in patients with a CTG TNR expansion and FECD disease (RE+/FECD+) were found normally spliced in RE+/FECD- samples.
|
31469403 |
2019 |
|
Hematopoietic Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
The general aim of the LBC ONC is to improve treatment of hematopoietic neoplasms by eradicating cancer-initiating and disease-propagating cells, also known as leukemic stem cells (LSC) in the context of leukemia.
|
30006759 |
2018 |
|
HTLV-I Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
The mechanism of p47 degradation is primarily dependent on activation of lysosomal-autophagy and the autophagy is activated in most of the HTLV-infected and ATLL cells, suggesting that the p47 degradation may be a first key molecular event during HTLV-1 infection to T-cells as a connector of two important signaling pathways, NF-κB and autophagy.
|
30837480 |
2019 |
|
Hypertrophic disorder of skin, unspecified
|
0.010 |
Biomarker
|
group |
BEFREE |
AKAP-Lbc-tethered PKA is implicated in cardiac hypertrophic signaling; however, mechanism of PKA action is unknown.
|
23045525 |
2012 |
|
Idiopathic Pulmonary Fibrosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
For rs62025270, the allele A associated with increased susceptibility to IPF was also associated with increased expression of AKAP13 mRNA in lung tissue from patients who had lung resection procedures (n=1111).
|
29066090 |
2017 |
|
Immunologic Deficiency Syndromes
|
0.010 |
Biomarker
|
group |
BEFREE |
Here, we identified the XIAP enzymatic substrate p47 as a positive regulator of the <i>I. scapularis</i> IMD network.
|
30559180 |
2019 |
|
Inflammatory Bowel Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
We have now established the PsiNCF1 to NCF1 ratio for a significant number of IBD patients (n = 488) and control subjects (n = 181) and show that there is no statistically significant difference between the frequency of the 1:1 ratio in CD (11.2%) or UC (12.2%) patients and controls (13.4%).
|
15626894 |
2004 |
|
Irritable Bowel Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
We have now established the PsiNCF1 to NCF1 ratio for a significant number of IBD patients (n = 488) and control subjects (n = 181) and show that there is no statistically significant difference between the frequency of the 1:1 ratio in CD (11.2%) or UC (12.2%) patients and controls (13.4%).
|
15626894 |
2004 |
|
Lean body mass
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomics of body fat percentage may contribute to sex bias in anorexia nervosa.
|
30593698 |
2019 |
|
leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The general aim of the LBC ONC is to improve treatment of hematopoietic neoplasms by eradicating cancer-initiating and disease-propagating cells, also known as leukemic stem cells (LSC) in the context of leukemia.
|
30006759 |
2018 |
|
Leukemia, Myelocytic, Acute
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The 4-year survival for MDS patients was 23% +/- 7% (s.e.), vs 50% +/- 18% (s.e.) for AML-LBC (P=0.048).
|
9009082 |
1997 |
|
Liver Cirrhosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We used LBC, based on SurePathTM (BD Diagnostics) technology, to screen 96 peritoneal fluid samples from patients with known malignancies and from 10 control patients with cirrhosis.
|
30024911 |
2018 |
|
Lung Diseases, Interstitial
|
0.100 |
GeneticVariation
|
group |
GWASDB |
Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.
|
23583980 |
2013 |