|
Diabetes Mellitus, Experimental
|
0.200 |
Biomarker
|
disease |
RGD |
Differential gene expression pattern of diabetic rat retinas after intravitreal injection of erythropoietin.
|
20973890 |
2011 |
|
Psoriasis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The abnormal expression level of TREX2 can result in broken chromosome, increased susceptibility to skin carcinogenesis and Psoriasis.
|
30357414 |
2018 |
|
Psoriasis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The importance of these enzymes to cutaneous integrity is observed when TREX1 and TREX2 pathways become aberrant, and autoimmune or cancerous diseases ensue.Manils et al. have now shown that overexpression of TREX2 may play a role in potentiating psoriasis.
|
27884288 |
2016 |
|
Psoriasis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Hence, our data indicate that Trex2 acts as a critical factor in the pathogenesis of psoriasis by promoting keratinocyte apoptosis and enucleation and thereby influencing skin immune responses.
|
27365293 |
2016 |
|
Skin Carcinogenesis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The abnormal expression level of TREX2 can result in broken chromosome, increased susceptibility to skin carcinogenesis and Psoriasis.
|
30357414 |
2018 |
|
Skin Carcinogenesis
|
0.020 |
Biomarker
|
disease |
BEFREE |
In mice, TREX2 deficiency led to enhanced susceptibility to UVB-induced skin carcinogenesis which was preceded by aberrant DNA damage removal and degradation as well as reduced inflammation.
|
26090614 |
2015 |
|
Malignant neoplasm of larynx
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
The data highlight a regulatory role of TREX2 DNA methylation for gene expression which might affect incidence and survival of laryngeal cancer.
|
31053176 |
2019 |
|
Colorectal Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We investigated the intragenic methylation loss at the three prime repair exonuclease 2 (TREX2) locus in laryngeal (n = 256) and colorectal cancer cases (n = 95) and in pan-cancer data from The Cancer Genome Atlas (TCGA).
|
31053176 |
2019 |
|
Carcinoma of larynx
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
The data highlight a regulatory role of TREX2 DNA methylation for gene expression which might affect incidence and survival of laryngeal cancer.
|
31053176 |
2019 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We investigated the intragenic methylation loss at the three prime repair exonuclease 2 (TREX2) locus in laryngeal (n = 256) and colorectal cancer cases (n = 95) and in pan-cancer data from The Cancer Genome Atlas (TCGA).
|
31053176 |
2019 |
|
Parakeratosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using Trex2 knockout mice, we have found that Trex2 deficiency attenuated IMQ-induced psoriasis-like skin inflammation and enhanced IMQ-induced parakeratosis.
|
27365293 |
2016 |
|
Auricular swelling
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Also, Il23-induced ear swelling was diminished in Trex2 knockout mice in comparison with wild-type (wt) mice.
|
27365293 |
2016 |
|
Squamous cell carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Moreover, we identified SNPs in the TREX2 gene that were more frequent in patients with head and neck SCCs than in healthy individuals.
|
26090614 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
No statistically significant association with the risk of SLE was observed in TREX1 and TREX2.
|
18092167 |
2008 |
|
Prostatic Neoplasms
|
0.010 |
GeneticVariation
|
group |
LHGDN |
Sequence variants in the 3'-->5' deoxyribonuclease TREX2: identification in a genetic screen and effects on catalysis by the recombinant proteins.
|
15581481 |
2004 |