Carcinoma, Basal Cell
|
0.020 |
Biomarker
|
disease |
BEFREE |
RNF139/TRC8 is a potential tumor suppressor gene with similarity to PTCH, a tumor suppressor implicated in basal cell carcinomas and glioblastomas.
|
19642973 |
2009 |
Clear-cell metastatic renal cell carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
These results confirm that balanced translocations disrupting the TRC8 and FHIT genes result in an increased genetic susceptibility for bilateral CC-RCC.
|
17539022 |
2007 |
Carcinoma, Basal Cell
|
0.020 |
Biomarker
|
disease |
BEFREE |
We now show that the 8q24.1 breakpoint region encodes a 664-aa multiple membrane spanning protein, TRC8, with similarity to the hereditary basal cell carcinoma/segment polarity gene, patched.
|
9689122 |
1998 |
Malignant neoplasm of kidney
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The TRC8 gene, which was previously shown to be disrupted by a 3;8 chromosomal translocation in hereditary kidney cancer, encodes for an endoplasmic reticulum-resident E3 ligase.
|
22689053 |
2013 |
Renal carcinoma
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The TRC8 gene, which was previously shown to be disrupted by a 3;8 chromosomal translocation in hereditary kidney cancer, encodes for an endoplasmic reticulum-resident E3 ligase.
|
22689053 |
2013 |
Malignant neoplasm of kidney
|
0.040 |
Biomarker
|
disease |
BEFREE |
RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene.
|
17016439 |
2007 |
Renal carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene.
|
17016439 |
2007 |
Malignant neoplasm of kidney
|
0.040 |
Biomarker
|
disease |
BEFREE |
Growth suppression induced by the TRC8 hereditary kidney cancer gene is dependent upon JAB1/CSN5.
|
15735686 |
2005 |
Renal carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Growth suppression induced by the TRC8 hereditary kidney cancer gene is dependent upon JAB1/CSN5.
|
15735686 |
2005 |
Malignant neoplasm of kidney
|
0.040 |
Biomarker
|
disease |
BEFREE |
Thus, VHL, TRC8, and JAB1 appear to be linked both physically and functionally and all three may participate in the development of kidney cancer.
|
12032852 |
2002 |
Renal carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Thus, VHL, TRC8, and JAB1 appear to be linked both physically and functionally and all three may participate in the development of kidney cancer.
|
12032852 |
2002 |
Neoplasms
|
0.060 |
GeneticVariation
|
group |
BEFREE |
As the tumor suppressor gene TRC8/RNF139 is disrupted by constitutional t(8;22)(q24.13;q11.21) in dysgerminoma, it may be associated with the onset of CML.
|
27686674 |
2017 |
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Studies have shown that TRC8 exhibits a tumor-suppressive effect through its E3-ligase activity.
|
22689053 |
2013 |
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
RNF139/TRC8 is a potential tumor suppressor gene with similarity to PTCH, a tumor suppressor implicated in basal cell carcinomas and glioblastomas.
|
19642973 |
2009 |
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
The presence of diploid and tetraploid tumor cells with and without TRC8 deletions on the nontranslocated chromosome suggest that loss of the remaining normal allele of TRC8 may contribute to tumor development at later stages.
|
17539022 |
2007 |
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Tumor formation in a nude mouse model is inhibited by TRC8 in a RING-dependent manner.
|
17016439 |
2007 |
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
On the basis of its chromosomal position, HRCA1 may be a candidate tumor suppressor gene.
|
7690964 |
1993 |
Isolated cases
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Chromophobe Renal Cell Carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
|
|
|
Sarcomatoid Renal Cell Carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
|
|
|
Collecting Duct Carcinoma of the Kidney
|
0.300 |
Biomarker
|
disease |
CTD_human |
|
|
|
Papillary Renal Cell Carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
|
|
|
Hereditary clear cell renal cell carcinoma
|
0.300 |
FusionGene
|
disease |
ORPHANET |
|
|
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma.
|
17539022 |
2007 |
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.320 |
Biomarker
|
disease |
BEFREE |
TRC8 encodes an E3-ubiquitin ligase disrupted in a family with hereditary renal cell carcinoma (RCC).
|
15735686 |
2005 |