PMF1, polyamine modulated factor 1, 11243

N. diseases: 11; N. variants: 31
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017654
Disease: Glomerular Filtration Rate
Glomerular Filtration Rate 		0.100 GeneticVariation phenotype GWASCAT Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies. 30604766 2019
CUI: C0023980
Disease: Longevity
Longevity 		0.100 GeneticVariation phenotype GWASCAT A meta-analysis of genome-wide association studies identifies multiple longevity genes. 31413261 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.100 GeneticVariation group GWASCAT Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. 29531354 2018
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke 		0.100 GeneticVariation disease GWASCAT Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. 29531354 2018
CUI: C2937358
Disease: Cerebral Hemorrhage
Cerebral Hemorrhage 		0.100 GeneticVariation phenotype GWASCAT Meta-analysis of genome-wide association studies identifies 1q22 as a susceptibility locus for intracerebral hemorrhage. 24656865 2014
CUI: C2937358
Disease: Cerebral Hemorrhage
Cerebral Hemorrhage 		0.100 GeneticVariation phenotype GWASDB Meta-analysis of genome-wide association studies identifies 1q22 as a susceptibility locus for intracerebral hemorrhage. 24656865 2014
CUI: C0005684
Disease: Malignant neoplasm of urinary bladder
Malignant neoplasm of urinary bladder 		0.020 PosttranslationalModification disease BEFREE In a retrospective design, PMF-1 methylation was analyzed on tumor specimens belonging to 108 patients with T1HG NMI bladder cancer undergoing BCG treatment. 22682992 2013
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.020 PosttranslationalModification disease BEFREE In a retrospective design, PMF-1 methylation was analyzed on tumor specimens belonging to 108 patients with T1HG NMI bladder cancer undergoing BCG treatment. 22682992 2013
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.020 PosttranslationalModification disease BEFREE In a retrospective design, PMF-1 methylation was analyzed on tumor specimens belonging to 108 patients with T1HG NMI bladder cancer undergoing BCG treatment. 22682992 2013
CUI: C0005684
Disease: Malignant neoplasm of urinary bladder
Malignant neoplasm of urinary bladder 		0.020 PosttranslationalModification disease BEFREE After identifying an enriched CpG island encompassing the PMF1 promoter, we aimed at evaluating the clinical relevance of PMF1 methylation in bladder cancer. 19088041 2008
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.020 PosttranslationalModification disease LHGDN An initial set of 101 primary frozen bladder tumors served to identify PMF1 hypermethylation in 88.1% of the cases. 19088041 2008
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.020 Biomarker disease BEFREE An initial set of 101 primary frozen bladder tumors served to identify PMF1 hypermethylation in 88.1% of the cases. 19088041 2008
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.020 PosttranslationalModification disease BEFREE After identifying an enriched CpG island encompassing the PMF1 promoter, we aimed at evaluating the clinical relevance of PMF1 methylation in bladder cancer. 19088041 2008
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.010 GeneticVariation group BEFREE Among the 108 patients analyzed, 35 had recurring disease (32.4%), 21 progressed (19.4%), and 16 died of disease (14.8%); 71.3% of tumors had PMF-1 methylation. 22682992 2013
CUI: C1827293
Disease: Carcinoma of urinary bladder, invasive
Carcinoma of urinary bladder, invasive 		0.010 Biomarker disease BEFREE Indeed, several studies have revealed that methylated genes--including CDH1, FHIT, LAMC2, RASSF1A, TIMP3, SFRP1, SOX9, PMF1 and RUNX3--are associated with poor survival in patients with MIBC. 23628807 2013
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.010 Biomarker phenotype BEFREE The association of PMF1 methylation with tumor progression and its diagnostic ability using urinary specimens support including PMF1 assessment for the clinical management of bladder cancer patients. 19088041 2008