USP18, ubiquitin specific peptidase 18, 11274

N. diseases: 79; N. variants: 2
Disease: HIV-1 infection ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection 		0.030 Biomarker disease BEFREE USP18 is a significant driver of memory CD4 T-cell reduced viability caused by type I IFN signaling during primary HIV-1 infection. 31658294 2019
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection 		0.030 Biomarker disease BEFREE This work clarifies the function and consequences of p53 modification by ISG15 and implicates USP18 in HIV-1 infection and potentially in carcinogenesis.<b>IMPORTANCE</b> HIV-1 has evolved many strategies to circumvent the host's antiviral innate immune responses and establishes disseminated infection; the molecular mechanisms of these strategies are not entirely clear. 31455647 2019
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection 		0.030 Biomarker disease BEFREE CRISPR/Cas9 knockout of USP18 enhances type I IFN responsiveness and restricts HIV-1 infection in macrophages. 29437254 2018