|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Serum IgE, IL-17A, IL-17F, and GR-β levels in geriatric patients with moderate or severe asthma were significantly higher than those in young patients with moderate asthma and in the normal population.
|
30304965 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Toluene diisocyanate (TDI) is one of the leading allergens of asthma that induces both T-helper Th2 and Th17 responses, and is often associated with poor responsiveness to steroid treatment in the clinic.We sought to evaluate the effects of inhaled and systemic steroids on a TDI-induced asthma model and to find how interleukin (IL)-17A and IL-17F function in this model.
|
30655284 |
2019 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We further found that the haplotype CT for IL-17F (rs763780/rs2397084) was associated with an increased susceptibility of asthma, but this association did not survive after FDR correction.
|
30036556 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-17F is involved in the pathogenesis of several inflammatory diseases, including asthma and COPD.
|
29649811 |
2018 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The correlation between IL-17F, mRNA, and level of asthma control was analyzed by using Pearson's correlation coefficient (r).
|
29968887 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-17F protein was also measured by ELISA in bronchial/nasal lysates and by immunohistochemistry in bronchial tissue obtained from subjects who died because of fatal asthma.
|
27931975 |
2017 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, while the 3 mg protein/ml SHE solution did not induce asthma, co-exposure with DEP resulted in a markedly enhanced AHR (p = 0.002) and eosinophilic inflammation (p = 0.004), with increased levels of IL-5, IL-17F and CCL20 and decreased levels of IFN-γ.
|
28628664 |
2017 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, specific antibody neutralization of either IL-17A or IL-17F given during the sensitization phase attenuated allergic lung inflammation and airway hyperreactivity.
|
29026003 |
2017 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study was conducted to evaluate the association of IL-10 (interleukin 10) and IL-17F (interleukin 17F) promoter polymorphisms (rs1800871, rs1800896 and rs1889570) with asthma and its clinical phenotypes including severity, atopic status, spirometric parameters, and response to treatment in south Indian population.
|
26108303 |
2015 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our systematic review showed that IL-17F rs1889570(C/T), IL-17A rs4711998(A/G) and IL-17A rs3819024(A/G) may be potential risk factors for asthma susceptibility.
|
26300019 |
2015 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated the possible association among asthma and IL-17A -197G/A (rs2275913), IL-17F 7488A/G (rs763780) and IL-17F 7383A/G (rs2397084).
|
24393079 |
2014 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In a case-control study of 867 unrelated Japanese subjects, a His161 to Arg161 (H161R) substitution in the third exon of the IL-17F gene was associated with asthma.
|
24829928 |
2014 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
T helper 17 (Th17) cells that produce interleukin (IL)-17A and IL-17F have been found to participate in the development of bronchial asthma and bleomycin-induced pulmonary fibrosis.
|
23400328 |
2013 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association between polymorphisms in IL17F and male asthma in a Chinese population.
|
22812194 |
2012 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to investigate whether polymorphisms in and around IL-17A and IL-17F genes are associated with AR and comorbid asthma.
|
22507625 |
2012 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Th17-associated cytokines, particularly IL-17A, IL-17F, and IL-22, have been postulated to play a role in the pathogenesis of asthma.
|
22898922 |
2012 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we confirmed that the rs1889570 polymorphism of the IL-17F gene is associated with susceptibility to asthma in a Korean population.
|
21196754 |
2011 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Levels of IL17A and IL17F were positively and significantly correlated in the asthma patients
|
22312940 |
2011 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, mice lacking either IL-17 or IL-17F exhibit distinct defects in experimental models of asthma and colitis.
|
19233684 |
2009 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Given that asthma and COPD are complex diseases involving a number of genetic and environmental factors, the genetic impact of IL-17F H161R with regard to the development of chronic airway inflammation likely varies among individuals with different genetic backgrounds and environmental exposures.
|
16961709 |
2006 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate the role of IL-17F in asthma pathogenesis, we conducted genetic analyses of association of asthma with the common variants of IL17F, using 867 unrelated Japanese subjects.
|
16630936 |
2006 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
None of the SNPs or haplotypes tested in IL17F were associated with asthma.
|
15703761 |
2005 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Identification of a novel cytokine, ML-1, and its expression in subjects with asthma.
|
11591768 |
2001 |