CHRM1, cholinergic receptor muscarinic 1, 1128

N. diseases: 68; N. variants: 2
Disease: Memory impairment ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.310 GeneticVariation phenotype BEFREE The memory deficits we observed in mouse prion disease were completely restored by treatment with benzyl quinolone carboxylic acid (BQCA) and benzoquinazoline-12 (BQZ-12), two highly selective positive allosteric modulators (PAMs) of M1 mAChRs. 27991860 2017
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.310 Biomarker phenotype CTD_human Discovery of a selective allosteric M1 receptor modulator with suitable development properties based on a quinolizidinone carboxylic acid scaffold. 21682298 2011