CHRM1, cholinergic receptor muscarinic 1, 1128

N. diseases: 68; N. variants: 2
Disease: Memory Loss ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.310 Biomarker phenotype BEFREE Thus, enhancing hippocampal muscarinic signaling using M1 mAChR PAMs restored memory loss and slowed the progression of mouse prion disease, indicating that this ligand type may have clinical benefit in diseases showing defective cholinergic transmission, such as AD. 27991860 2017
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.310 Biomarker phenotype CTD_human Discovery of a selective allosteric M1 receptor modulator with suitable development properties based on a quinolizidinone carboxylic acid scaffold. 21682298 2011