CHRM2, cholinergic receptor muscarinic 2, 1129

N. diseases: 91; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.340 GeneticVariation disease BEFREE In this study, we evaluated whether genetic variation in the CHRM2 gene is also a risk factor for the correlated clinical characteristics of alcoholism and depression. 15229186 2004
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.340 GeneticVariation disease BEFREE Genetic variation in the cholinergic muscarinic-2 (M(2)) receptor gene (CHRM2) has been associated with the risk for developing depression. 20351719 2011
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.340 Biomarker disease PSYGENET Our data fail to support association with the CHRM2 polymorphisms previously implicated in the genetic aetiology of depression. 19181679 2009
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.340 Biomarker disease PSYGENET Genetic variation in the cholinergic muscarinic-2 (M(2)) receptor gene (CHRM2) has been associated with the risk for developing depression. 20351719 2011
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.340 GeneticVariation disease BEFREE Our data fail to support association with the CHRM2 polymorphisms previously implicated in the genetic aetiology of depression. 19181679 2009
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.340 Biomarker disease PSYGENET These results are consistent with a gender-specific role of the CHRM2 gene in depression in women. 12116189 2002
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.340 Biomarker disease BEFREE These results are consistent with a gender-specific role of the CHRM2 gene in depression in women. 12116189 2002
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 GeneticVariation disease BEFREE The authors tried to verify this hypothesis by testing for possible associations between two muscarinic receptor genes (CHRM1 and CHRM2) polymorphisms and TD in patients with schizophrenia. 30623717 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 Biomarker disease PSYGENET These deficits were related to SNPs from 16 genes, several previously associated with schizophrenia risk and/or involved in normal central nervous system development, including AKT, PI3K, SLC6A4, DRD2, CHRM2, and ADORA2A. 20691427 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 GeneticVariation disease BEFREE CHRM2 polymorphisms may play an important role in ANS activity in patients with schizophrenia. 27923235 2016
CUI: C0038580
Disease: Substance Dependence
Substance Dependence 		0.320 Biomarker disease CTD_human Altered neural cholinergic receptor systems in cocaine-addicted subjects. 20393457 2010
CUI: C0038580
Disease: Substance Dependence
Substance Dependence 		0.320 Biomarker disease BEFREE We assessed dimensions of the five-factor model of personality, and genotyped six CHRM2 markers and 38 unlinked ancestry-informative markers in 239 subjects with SD [173 European-Americans (EAs) and 66 African-Americans (AAs)] and 275 healthy subjects (237 EAs and 38 AAs). 17468496 2007
CUI: C0038580
Disease: Substance Dependence
Substance Dependence 		0.320 GeneticVariation disease BEFREE This group also showed a greater prevalence of a CHRM2 genotype previously associated with substance dependence and Major Depressive Disorder as well as a modest elevation on a non-planning impulsiveness scale. 24530440 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.310 Biomarker disease PSYGENET These data represent novel preliminary evidence that reduced M(2)-receptor V(T) in BD is associated with genetic variation within CHRM2. 20351719 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.310 GeneticVariation disease BEFREE These data represent novel preliminary evidence that reduced M(2)-receptor V(T) in BD is associated with genetic variation within CHRM2. 20351719 2011
CUI: C0005697
Disease: Neurogenic Urinary Bladder
Neurogenic Urinary Bladder 		0.310 Biomarker disease LHGDN The M2 muscarinic receptor mediates in vitro bladder contractions from patients with neurogenic bladder dysfunction. 14751843 2004
CUI: C0005697
Disease: Neurogenic Urinary Bladder
Neurogenic Urinary Bladder 		0.310 Therapeutic disease CTD_human The M2-muscarinic receptor inhibits the development of streptozotocin-induced neuropathy in mouse urinary bladder. 20624991 2010
CUI: C0014544
Disease: Epilepsy
Epilepsy 		0.310 GeneticVariation disease BEFREE Genetic polymorphisms of CYP3A5, CHRM2, and ZNF498 and their association with epilepsy susceptibility: a pharmacogenetic and case-control study. 31564953 2019
CUI: C0014544
Disease: Epilepsy
Epilepsy 		0.310 Biomarker disease CTD_human Acetylcholine-induced seizure-like activity and modified cholinergic gene expression in chronically epileptic rats. 18333967 2008
CUI: C0002152
Disease: Alloxan Diabetes
Alloxan Diabetes 		0.300 Biomarker disease CTD_human Increase of cardiac M2-muscarinic receptor gene expression in type-1 but not in type-2 diabetic rats. 18603373 2008
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.300 Biomarker disease CTD_human Increase of cardiac M2-muscarinic receptor gene expression in type-1 but not in type-2 diabetic rats. 18603373 2008
CUI: C0011854
Disease: Diabetes Mellitus, Insulin-Dependent
Diabetes Mellitus, Insulin-Dependent 		0.300 Biomarker disease CTD_human Increase of cardiac M2-muscarinic receptor gene expression in type-1 but not in type-2 diabetic rats. 18603373 2008
CUI: C0029231
Disease: Organic Mental Disorders, Substance-Induced
Organic Mental Disorders, Substance-Induced 		0.300 Biomarker disease CTD_human Altered neural cholinergic receptor systems in cocaine-addicted subjects. 20393457 2010
CUI: C0038433
Disease: Streptozotocin Diabetes
Streptozotocin Diabetes 		0.300 Biomarker disease CTD_human Increase of cardiac M2-muscarinic receptor gene expression in type-1 but not in type-2 diabetic rats. 18603373 2008
CUI: C0086237
Disease: Epilepsy, Cryptogenic
Epilepsy, Cryptogenic 		0.300 Biomarker disease CTD_human Acetylcholine-induced seizure-like activity and modified cholinergic gene expression in chronically epileptic rats. 18333967 2008