PLCD3, phospholipase C delta 3, 113026

N. diseases: 11; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0871470
Disease: Systolic Pressure
Systolic Pressure 		0.100 GeneticVariation phenotype GWASCAT Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation. 27841878 2017
CUI: C0005823
Disease: Blood Pressure
Blood Pressure 		0.100 GeneticVariation phenotype GWASDB Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. 21378095 2011
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.100 GeneticVariation disease GWASDB Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. 21347282 2011
CUI: C1306620
Disease: Systolic blood pressure measurement
Systolic blood pressure measurement 		0.100 GeneticVariation phenotype GWASDB Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. 21909115 2011
CUI: C0871470
Disease: Systolic Pressure
Systolic Pressure 		0.100 GeneticVariation phenotype GWASCAT Genome-wide association study identifies eight loci associated with blood pressure. 19430483 2009
CUI: C1306620
Disease: Systolic blood pressure measurement
Systolic blood pressure measurement 		0.100 GeneticVariation phenotype GWASDB Genome-wide association study identifies eight loci associated with blood pressure. 19430483 2009
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.010 AlteredExpression disease BEFREE In PDAC patients, PLCD3 is overexpressed in certain groups of people with a history of alcoholism (P = .032). 31808619 2020
CUI: C1832661
Disease: ANOPHTHALMIA AND PULMONARY HYPOPLASIA
ANOPHTHALMIA AND PULMONARY HYPOPLASIA 		0.010 Biomarker disease BEFREE A combination of PLCD3 and clinical variables was able to better predict the outcome of patients with early stage PDAC. 31808619 2020
CUI: C0001857
Disease: AIDS related complex
AIDS related complex 		0.010 AlteredExpression disease BEFREE The expression of lncRNA PLCD3-OT1 and PLCD3 were significantly decreased in ARC. 31725166 2019
CUI: C0036646
Disease: Age-related cataract
Age-related cataract 		0.010 Biomarker disease BEFREE This study aimed to conduct global lncRNA profiling and characterize the role of lncRNA 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 3-sence RNA 1 (PLCD3-OT1) in the progression of age-related cataract (ARC). 31725166 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.010 Biomarker phenotype BEFREE PLCD3, a flotillin2-interacting protein, is involved in proliferation, migration and invasion of nasopharyngeal carcinoma cells. 29115528 2018
CUI: C2931822
Disease: Nasopharyngeal carcinoma
Nasopharyngeal carcinoma 		0.010 Biomarker disease BEFREE The present study demonstrated that PLCD3 may be an oncogenic protein in NPC and that it plays an important role in the progression of NPC partially by interacting with Flot2. 29115528 2018
CUI: C3495417
Disease: Hemifacial microsomia
Hemifacial microsomia 		0.010 GeneticVariation disease BEFREE External environmental factors (e.g., thalidomide, triazene, retinoic acid, and vasoactive medications), maternal intrinsic factors (e.g., maternal diabetes), and genetic factors (e.g., the recently reported mutations in OTX2, PLCD3, and MYT1) may lead to HFM through ≥1 of these pathogenic processes. 30205013 2018