|
Liver neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
<i>T.Diversifolia</i> leaves were first extracted in ethyl acetate, then further fractionated by different ratio of <i>n</i>-hexane/ethyl acetate (8:2→0:1) or methanol.These extracts exhibit growth inhibition on human hepatoma (HCC) HepG2 cells.<i>n</i>-Hexane/ethyl acetate (6:4) extract (Td-F2) induces apoptosis of HCC.<b>Abbreviations used:</b><i>T. diversifolia</i>, <i>Tithonia diversifolia</i>; HCC, Hepatocellular carcinoma DMEM, Dulbecco's modified Eagle's medium; DMSO, dimethyl sulfoxide; HRP, horseradish peroxidase; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; OD, optical density; SDS-PAGE, sodium dodecylsulfate-polyacrylamide gel electrophoresis; PARP, Poly (ADP-ribose) polymerase; PBS, phosphate buffered saline; PI, propidium iodide.
|
29200736 |
2019 |
|
Marijuana Abuse
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A regulatory variant of CHRM3 is associated with cannabis-induced hallucinations in European Americans.
|
31740666 |
2019 |
|
Mydriasis
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
This is the first independent report of biallelic variants in CHRM3 in a family with a rare serious bladder disorder associated with mydriasis and provides important evidence of this association.
|
31441039 |
2019 |
|
Nephroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In a preclinical dosage study, B440 significantly inhibited growth of the TRAMP-C2 tumors compared with that of the control groups (PBS and <i>B. longum</i> not expressing WT1) at all dosages (1, 5, and 10 mg/body of B440).
|
30824610 |
2019 |
|
Osteogenesis Imperfecta
|
0.010 |
Biomarker
|
disease |
BEFREE |
Abbreviations: ADO: allele dropout; DI: dentinogenesis imperfect; ESHRE: European Society of Human Reproduction and Embryology; FET: frozen embryo transfer; gDNA: genomic DNA; ICSI: intracytoplasmic sperm injection; IVF: in vitro fertilization; MDA: multiple displacement amplification; NGS: next-generation sequencing; OI: osteogenesis imperfect; PBS: phosphate buffer saline; PCR: polymerase chain reaction; PGD: preimplantation genetic diagnosis; SNP: single-nucleotide polymorphism; STR: short tandem repeat; TE: trophectoderm; WGA: whole-genome amplification.
|
29764212 |
2019 |
|
Osteopenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Compared with Ti + PBS and Ti + Lip group, macrophage density (1.64 ± 0.86%) infiltrated into peri-implant tissue and bone loss (0.17 ± 0.03 mm) around implant decreased significantly in the Ti + LipClod group.
|
30635919 |
2019 |
|
Paracoccidioidomycosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Most importantly, three doses of pVAX1-PB_HSP60 and protein induced a beneficial effect in experimental PCM with a reduction in fungal load and lung injury when compared with infected mice treated with pVAX1 or PBS.
|
31399276 |
2019 |
|
Parasitic Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
A 3 × 4 factorial design with three parasite infection groups (Lm, Sm, Lm + Sm to represent L. major, S. mansoni and L. major + S. mansoni respectively) and four treatment regimens [P, PZQ, P + PZQ, and PBS designating Pentostam (GlaxoSmithKline UK), Praziquantel (Biltricide<sup>®</sup>, Bayer Ag.
|
31348915 |
2019 |
|
Psychotic Disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
CHRM3 was co-expressed with three psychosis risk genes (GABAG2, CHRNA4, and HRH3) in the thalamus and other human brain tissues and mouse GABAergic neurons.
|
31740666 |
2019 |
|
Septicemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
To determine the ScaF potential as a vaccine candidate, experimental groups of mice were immunized with recombinant Scaf (r-ScaF) formulated in Freund's and alum adjuvants or PBS and subsequently challenged in the sepsis model of S. aureus disease.
|
30521844 |
2019 |
|
Subarachnoid Hemorrhage
|
0.010 |
Biomarker
|
disease |
BEFREE |
Rats were randomly divided into five groups: Sham, SAH + Vehicle (PBS, phosphate-buffered saline), SAH + rOPN (5 μg/rat recombinant OPN), SAH + rOPN + Fib-14 (30 mg/kg of focal adhesion kinase (FAK) inhibitor-14), and SAH + rOPN + DMSO (dimethyl sulfoxide).
|
31461955 |
2019 |
|
Virus Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Our findings provide the evidence that Rig-I is a key regulator of cellular senescence, which will be helpful in better understanding its function without viral infection.<b>Abbreviations:</b> Rig-I: retinoic acid inducible gene-I; SASP: senescence-associated secretory phenotype; ECM: extracellular matrix; Itgb3: integrin beta 3; PRR: pattern recognition receptor; MEFs: mouse embryonic fibroblasts; Il-1β: interleukin-1 beta; Il-6: interleukin-6; Il-8: interleukin-8; Cxcl1: chemokine (C-X-C motif) ligand 1; Ccl2: chemokine (C-C motif) ligand 2; WT, wild type; BM: bone marrow; MAPK: mitogen-activated protein kinase; ERK: extracellular signal-regulated kinases; JNK: Jun N-terminal kinases; SA-β-gal: senescence-associated β-galactosidase; qPCR: quantitative reverse-transcription PCR; PBS: phosphate-buffered saline.
|
31595820 |
2019 |
|
Dental White Spot
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In this study, we sequenced six cDNA libraries prepared with hemocytes from Litopenaeus vannamei which were injected by WSSV (white spot syndrome virus) or PBS for 6 h using Illumina Hiseq 4000 platform.
|
30922216 |
2019 |
|
Gestational Diabetes
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
GDM was induced by feeding pregnant mice a HFD, and mice were treated with two different doses of metformin (300 and 600 mg/kg/day) or PBS between embryonic day 11.5 (E11.5) and E17.5.
|
30896853 |
2019 |
|
Ovarian Failure, Premature
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thirty adult female rats were randomly subdivided into five groups: normal control (control), cyclophosphamide (CTX) plus subsequent PBS (POI + PBS), CTX plus subsequent PRP (POI + PRP), CTX plus subsequent G-CSF-mobilized PBMCs (POI + PBMCs), and CTX plus subsequent G-CSF-mobilized PBMCs combined with PRP (POI + PBMCs + PRP).
|
31034039 |
2019 |
|
Polyendocrinopathies, Autoimmune
|
0.010 |
Biomarker
|
group |
BEFREE |
β2GPI immunized mice developed experimental APS which were fed with domain-I significantly had decreased fetal loss (p < 0.004), a lower size of thrombi (p < 0.001) and lower circulating anti-β2GPI Abs in comparison to mice fed with domain-V or PBS (p < 0.002).
|
30797663 |
2019 |
|
Russell-Silver syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Compared with the PBS group, the overall frequency and duration of SRS significantly decreased in the transplantation group, especially in the GABA group (P < 0.01).
|
30790741 |
2019 |
|
Sepsis
|
0.010 |
Biomarker
|
disease |
BEFREE |
To determine the ScaF potential as a vaccine candidate, experimental groups of mice were immunized with recombinant Scaf (r-ScaF) formulated in Freund's and alum adjuvants or PBS and subsequently challenged in the sepsis model of S. aureus disease.
|
30521844 |
2019 |
|
Chronic heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
Transverse aortic constriction was performed to induce chronic heart failure in the puerarin an PBS groups.
|
31602208 |
2019 |
|
Vascular calcification
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Approach and Results- We quantified and investigated mechanisms of vascular remodeling and vascular calcification in ob/ob mice after vitamin D<sub>3</sub>(VD) stimulation or PBS (control), compared with C57BL/6 mice.
|
30580565 |
2019 |
|
Nonorganic psychosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CHRM3 was co-expressed with three psychosis risk genes (GABAG2, CHRNA4, and HRH3) in the thalamus and other human brain tissues and mouse GABAergic neurons.
|
31740666 |
2019 |
|
Non-alcoholic Fatty Liver Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Abbreviations: BSA: Bovine serum albumin; CIDEs: Cell Death Inducing DFFA Like Effectors; DMEM, Dulbecco's Modified Eagle's Medium; FABPs: Fatty Acid Binding Proteins; FAT/CD36: Fatty acid translocase; FCS: Fetal calf serum; GLP2: Glucagon-like peptide-2; NAFLD: Nonalcoholic fatty liver disease; OA: oleic acid; PBS: Phosphate buffer saline; PPARs: Peroxisome-Proliferator Activated Receptors; RTCA: realtime cell analysis; TG: triglyceride.
|
30905315 |
2019 |
|
Osteoarthritis, Knee
|
0.010 |
Biomarker
|
disease |
BEFREE |
Forty-eight rats were randomized into four experimental groups: control group, OA group, OA + PBS group, and OA + curcumin group, respectively.
|
30663793 |
2019 |
|
Oropharynx (excludes nasopharynx)
|
0.010 |
Biomarker
|
disease |
BEFREE |
PM<sub>2.5</sub>/PBS exposure was administered by oropharynx instillation every other day and HT supplementation was achieved by gavage every day.
|
31279968 |
2019 |
|
Oropharyngeal disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
MWCNTs with or without ESAT-6 peptide 14 were instilled by the oropharyngeal route into macrophage-specific PPARγ-knockout (KO) or wild-type mice.Control animals received PBS or ESAT-6.
|
30741559 |
2019 |