CHRM3, cholinergic receptor muscarinic 3, 1131

N. diseases: 284; N. variants: 17
Disease: Encephalomyelitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis 		0.040 Biomarker disease BEFREE We found that intravenous administration of exosomes produced by MSCs stimulated by IFNγ (IFNγ-Exo) (i) reduced the mean clinical score of EAE mice compared to PBS control, (ii) reduced demyelination, (iii) decreased neuroinflammation, and (iv) upregulated the number of CD4+CD25+FOXP3+ regulatory T cells (Tregs) within the spinal cords of EAE mice. 31117376 2019
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis 		0.040 GeneticVariation disease BEFREE Mice were treated intraperitoneally for five consecutive days with either PBS or 300 μg of orexin A starting at a moderate EAE score. 30894198 2019
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis 		0.040 Biomarker disease BEFREE The ratio of IFN-γ/IL-4, an indicator of Th-1/Th-2, was significantly higher in PBS- and melatonin- treated EAE rats, in comparison to controls. 27696474 2017
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis 		0.040 Biomarker disease BEFREE Rats in EAE and TWP groups received injections of emulsified EAE antigen (myelin protein) at two points on the footpad while control group received PBS. 28983582 2017