CDCA5, cell division cycle associated 5, 113130

N. diseases: 105; N. variants: 3
Disease: Neurodegenerative Disorders ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0524851
Disease: Neurodegenerative Disorders
Neurodegenerative Disorders 		0.040 Biomarker group BEFREE Under neurotoxic conditions, p35 undergoes proteolytic cleavage to liberate p25, which has been implicated in various neurodegenerative diseases. 24725413 2014
CUI: C0524851
Disease: Neurodegenerative Disorders
Neurodegenerative Disorders 		0.040 Biomarker group BEFREE The activity of Cdk5 and its regulatory subunit p35 is thought to be important in both normal brain function and neurodegenerative disease pathogenesis. 21844361 2011
CUI: C0524851
Disease: Neurodegenerative Disorders
Neurodegenerative Disorders 		0.040 Biomarker group BEFREE It has been widely accepted that aberrant Cdk5 activity induced by the conversion of p35 to p25 plays roles in the pathogenesis of neurodegenerative diseases. 17979810 2007
CUI: C0524851
Disease: Neurodegenerative Disorders
Neurodegenerative Disorders 		0.040 Biomarker group BEFREE These results suggest that p35 transduction of neurons by viral vectors could be therapeutically useful in the treatment of human neurodegenerative diseases. 15307952 2004