ECD, ecdysoneless cell cycle regulator, 11319

N. diseases: 40; N. variants: 1
Disease: Split hand foot deformity 1 ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2931019
Disease: Split hand foot deformity 1
Split hand foot deformity 1 		0.020 Biomarker disease BEFREE Further, binding of an agonistic antibody (MM12) specific to human TrkB-EJM activated the full-length TrkB and unexpectedly also truncated TrkB lacking ECD (TrkBdelECD365), suggesting that TrkB is activated by attenuating the inhibitory effect of EJM through MM12 binding-induced conformational changes. 31430955 2019
CUI: C2931019
Disease: Split hand foot deformity 1
Split hand foot deformity 1 		0.020 Biomarker disease BEFREE Curiously, mice immunized with the human EGFR-ECD (Her1-ECD) in VSSP though induced highly specific IgG antibodies with strong in vitro cytotoxic effect over EGFR+ human cell lines, showed low cross-reactivity with the mEGFR-ECD. 16841332 2006