|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Among the genes identified, we selected glucocorticoid-induced transcript 1 (<i>GLCCI1</i>) and stress-induced phosphoprotein 1 (<i>STIP1</i>) to evaluate the impact of these gene polymorphisms on ICS treatment response in Tunisian asthmatics.
|
31516081 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The hazard ratios for asthma exacerbation in patients with low GLCCI1, Nrf2, and HDAC2 mRNA expression levels were 3.24 (95% confidence interval, 1.42-7.40), 3.13 (1.37-7.16), and 2.98 (1.22-7.25), respectively.
|
31391381 |
2019 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
GLCCI1 Polymorphism rs37973 and Response to Treatment of Asthma With Inhaled Corticosteroids.
|
29345236 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Asthma model was constructed in wild-type and GLCCI1 knockout (GLCCI1<sup>-/-</sup>) mice.
|
30511684 |
2018 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A variant of the glucocorticoid-induced transcript 1 (GLCCI1) genes has previously been associated with decreased lung function improvement upon treatment with ICSs in patients with bronchial asthma.
|
28488322 |
2018 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The glucocorticoid-induced transcript 1 (GLCCI1) promoter polymorphism (rs37972) has been reported to be associated with response to glucocorticoid therapy in asthma.
|
29224020 |
2017 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, the levels of some cytokines were significantly reduced after glucocorticoid treatment in individuals with the AA and AG genotypes.The genetic variant rs37973 in GLCCI1 is associated with poorer clinical therapeutic response to inhaled glucocorticoids in a Chinese asthma population.
|
29384926 |
2017 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, we analyzed the association of GLCCI1 variations with ICS response in 30 mild-to-moderate asthmatics.
|
27133712 |
2016 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Eighty-two children (56 boys/26 girls, mean age 9.6 ± 3.2 years) with moderate-severe asthma exacerbation were genotyped for eight single-nucleotide polymorphisms that were a priori associated with ICS response in chronic asthma treatment: glucocorticosteroid receptor (NR3C1) rs41423247; corticotrophin-releasing hormone receptor1 (CRHR1) rs242939, rs242941, and rs1876828; T-box 21 (TBX21) rs2240017; glucocorticoid-induced transcript 1 (GLCCl1); and T gene rs3099266 and rs2305089.
|
27003716 |
2016 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Neutrophils isolated from the blood were cultured with dexamethasone and/or atopic asthmatic serum for 18 h. The mRNA expression of mitogen-activated protein kinase phosphatase-1 (MKP-1), a glucocorticoid transactivation target, and glucocorticoid-induced transcript 1 (GLCCI1), an early marker of glucocorticoid-induced apoptosis whose expression was associated with the response to inhaled glucocorticoids in asthma , was determined by real-time PCR, and ELISA was used to assess the pro-inflammatory cytokine IL-8 levels in the supernatant.
|
27852250 |
2016 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Rs37972 and rs37973 variants in the glucocorticoid-induced transcript 1 gene have been associated with inhaled glucocorticosteroid responsiveness in asthmatics; however, some discrepancies have been also reported.
|
25134782 |
2015 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pharmacogenetic analysis of GLCCI1 in three north European pediatric asthma populations with a reported use of inhaled corticosteroids.
|
24897287 |
2014 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Variants of glucocorticoid induced transcript 1 (GLCCI1) result decreased response to inhaled corticosteroids, while intronic variant of low-affinity IgE receptor (FCER2) is associated with exacerbation rates in children with asthma.
|
25091946 |
2014 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A GLCCI1 variant is a risk factor of pulmonary function decline in Japanese patients with asthma receiving long-term ICS treatment.
|
24673601 |
2014 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma.
|
21991891 |
2011 |