|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
High CBX3 expression was dependent on the tumor size, Karnofsky performance scale (KPS) score, WHO grade, recurrence and survival status.
|
31502042 |
2019 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
CBX3/HP1γ promotes tumor proliferation and predicts poor survival in hepatocellular carcinoma.
|
31375643 |
2019 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Upregulation of CBX3/HP1-gamma in tumor samples was present in 60.2% of the patients.
|
29124886 |
2018 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
CBX3 promotes tumor proliferation by regulating G1/S phase via p21 downregulation and associates with poor prognosis in tongue squamous cell carcinoma.
|
29462646 |
2018 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Overexpression of CBX3 induced the in vitro proliferation, anchorage-free growth, migration and invasion of the PAAD cells, and led to in vivo growth of orthotoptic PAAD tumors in mice.
|
29903985 |
2018 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Together these changes in the tumor immune environment may have mitigated tumor burden in Cbx3/HP1γ-insufficient mice or wild type mice treated with Cbx3/HP1γ-insufficient CD8<sup>+</sup> T cells.
|
28220815 |
2017 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
We identified miR-30a as a tumor-suppressive microRNA that targets HP1γ in vitro and in vivo to specifically suppress the growth of colorectal cancer in mouse xenograft models.
|
26333808 |
2015 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Here, we show distinct cell-type- and cancer-stage-associated patterns of key heterochromatin marks: histone H3 trimethylated at lysine 9 (H3K9me3) and heterochromatic adaptor proteins HP1α and HP1γ, compared with the γH2AX marker of endogenously activated DNA damage response (DDR) and proliferation markers in normal human foetal (n=4) and adult (n=29) testes, pre-invasive carcinoma in situ (CIS; n=26) lesions and a series of overt germ cell tumours, including seminomas (n=26), embryonal carcinomas (n=18) and teratomas (n=11).
|
20695923 |
2011 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
CBX3, namely chromobox protein homolog 3, a member of the heterochomatin protein 1 (HP1) family, has been shown to be associated with the tumorigenesis of various types of cancer.
|
30942427 |
2019 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
CBX3 predicts an unfavorable prognosis and promotes tumorigenesis in osteosarcoma.
|
30942427 |
2019 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
CBX3, namely chromobox protein homolog 3, a member of the heterochomatin protein 1 (HP1) family, has been shown to be associated with the tumorigenesis of various types of cancer.
|
30942427 |
2019 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
CBX3/HP1-gamma is an isoform of the heterochromatin protein 1 family, which plays a role in heterochromatin formation and is linked to cancer.
|
29124886 |
2018 |
|
Malignant Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
These findings highlight the importance of HP1γ and its reader activity in lung adenocarcinoma tumorigenesis and reveal a unique lung adenocarcinoma-promoting mechanism in which HP1γ downregulates NCOR2 and ZBTB7A to enhance expression of protumorigenic genes.<b>Significance:</b> Direct epigenetic repression of the transcription-repressive regulators NCOR2 and ZBTB7A by the histone reader protein HP1γ leads to activation of protumorigenic genes in lung adenocarcinoma.<i>Cancer Res; 78(14); 3834-48.©2018 AACR</i>.
|
29764865 |
2018 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
More and more evidence has demonstrated that Chromobox protein homolog 3(CBX3) has an important role in carcinogenesis by regulating several mechanisms, such as heterochromatin formation, gene silencing, DNA replication and repair.
|
29678579 |
2018 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
These findings suggest that CBX3/HP1γ may serve an important role in tongue tumorigenesis and may be a valuable candidate diagnostic and prognostic marker for TSCC patients.
|
29731822 |
2018 |
|
Carcinogenesis
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
These findings highlight the importance of HP1γ and its reader activity in lung adenocarcinoma tumorigenesis and reveal a unique lung adenocarcinoma-promoting mechanism in which HP1γ downregulates NCOR2 and ZBTB7A to enhance expression of protumorigenic genes.<b>Significance:</b> Direct epigenetic repression of the transcription-repressive regulators NCOR2 and ZBTB7A by the histone reader protein HP1γ leads to activation of protumorigenic genes in lung adenocarcinoma.<i></i>.
|
29764865 |
2018 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Heterochromatin protein 1γ (HP1γ) has been implicated in carcinogenesis of various cancer types.
|
28967902 |
2018 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
CBX3/HP1-gamma is an isoform of the heterochromatin protein 1 family, which plays a role in heterochromatin formation and is linked to cancer.
|
29124886 |
2018 |
|
Primary malignant neoplasm
|
0.060 |
AlteredExpression
|
group |
BEFREE |
These findings highlight the importance of HP1γ and its reader activity in lung adenocarcinoma tumorigenesis and reveal a unique lung adenocarcinoma-promoting mechanism in which HP1γ downregulates NCOR2 and ZBTB7A to enhance expression of protumorigenic genes.<b>Significance:</b> Direct epigenetic repression of the transcription-repressive regulators NCOR2 and ZBTB7A by the histone reader protein HP1γ leads to activation of protumorigenic genes in lung adenocarcinoma.<i>Cancer Res; 78(14); 3834-48.©2018 AACR</i>.
|
29764865 |
2018 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Heterochromatin protein 1γ (CBX3) links histone methylation marks to transcriptional silence, DNA repair and RNA splicing, but a role for CBX3 in cancer remains largely unknown.
|
28193906 |
2017 |
|
Carcinogenesis
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
Our results demonstrate a key role of CBX3 in colon carcinogenesis via suppressing the expression of CDK6/p21, which may disrupt the role of CDK6 in transcriptionally regulating p21, as part of a negative feedback loop to limit CDK6 excessive activation.
|
28193906 |
2017 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
Heterochromatin protein 1γ (CBX3) links histone methylation marks to transcriptional silence, DNA repair and RNA splicing, but a role for CBX3 in cancer remains largely unknown.
|
28193906 |
2017 |
|
Malignant Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
In tissue arrays, quantitative imaging detects increased GLB1 expression in high-grade prostatic intraepithelial neoplasia (HGPIN), known to contain senescent cells, and cancer compared to benign prostate tissues (p<0.01) and senescent cells contain low Ki67 and elevated HP1γ.
|
25876105 |
2015 |
|
Primary malignant neoplasm
|
0.060 |
AlteredExpression
|
group |
BEFREE |
In tissue arrays, quantitative imaging detects increased GLB1 expression in high-grade prostatic intraepithelial neoplasia (HGPIN), known to contain senescent cells, and cancer compared to benign prostate tissues (p<0.01) and senescent cells contain low Ki67 and elevated HP1γ.
|
25876105 |
2015 |
|
Malignant Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
In this first detailed analysis of HP1γ expression in cancer, VECTRA™ demonstrates compartmentalized and total HP1γ protein expression is increased in PCa and that expression correlates with clinical outcomes better than Gleason score.
|
23522301 |
2013 |