MGLL, monoglyceride lipase, 11343

N. diseases: 125; N. variants: 7
Disease: Cannabis Dependence ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006870
Disease: Cannabis Dependence
Cannabis Dependence 		0.020 AlteredExpression disease BEFREE Spatial patterns of gray matter differences in CD were significantly associated with regional differences in monoacylglycerol lipase (MAGL) expression in postmortem brain tissue, such that regions with higher MAGL expression (but not fatty-acid amide hydrolase or FAAH) were more vulnerable to cortical thinning. 31695165 2019
CUI: C0006870
Disease: Cannabis Dependence
Cannabis Dependence 		0.020 Biomarker disease BEFREE These results are consistent with rodent models implicating 2-arachidonoylglycerol (2-AG), an endogenous cannabinoid metabolized by the enzyme encoded by MGLL, in the etiology of stress adaptation related to cannabis dependence, but require further replication. 26595473 2015