SYNPO, synaptopodin, 11346

N. diseases: 37; N. variants: 3
Disease: Alzheimer's Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.010 Biomarker disease BEFREE These experiments indicate that a reduction in the expression of SP ameliorates AD-associated phenotype in 3xTg mice.<b>SIGNIFICANCE STATEMENT</b> This study strengthens the proposed role of calcium stores in the development of AD-associated phenotype in the 3xTg mouse model, in that a genetic reduction of the functioning of ryanodine receptors using synaptopodin-knock-out mice ameliorates AD symptoms at the behavioral, electrophysiological, and morphological levels of analysis. 30872324 2019