NLRP3, NLR family pyrin domain containing 3, 114548

N. diseases: 805; N. variants: 74
Disease: Celiac Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.040 GeneticVariation disease BEFREE Further, stratification by disease type showed a significant association of the NLRP3 rs10754558 C allele with SLE (OR = 1.465 95% CI = 1.144-1.875, p = 0.002) but not with gout and celiac disease. 27060062 2016
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.040 Biomarker disease BEFREE Thus, innate immune pathways, such as TLR2/4/MyD88/TRIF/MAPK/NF-κB and an NLRP3 inflammasome activation are involved in wheat proteins signaling and may play an important role in the pathogenesis of CD. 23658628 2013
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.040 Biomarker disease BEFREE We hypothesized that the deregulation of CIAS1/NALP3/NLRP3 and NALP1/NLRP1 inflammasomes could have a role in CD pathogenesis. 21245836 2011
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.040 GeneticVariation disease BEFREE Two SNPs in NLRP3 gene are involved in the predisposition to type-1 diabetes and celiac disease in a pediatric population from northeast Brazil. 20370570 2010