|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We studied the effect of heat-killed cells of <i>E. faecalis</i> on NLRP3 inflammasome activation in THP-1-derived macrophages.Pretreatment of <i>E. faecalis</i> or NLRP3 siRNA can inhibit NLRP3 inflammasome activation in macrophages in response to fecal content or commensal microbes, <i>P. mirabilis</i> or <i>E. coli</i>, according to the reduction of caspase-1 activation and IL-1β maturation.Mechanistically, <i>E. faecalis</i> attenuates the phagocytosis that is required for the full activation of the NLRP3 inflammasome.In in vivo mouse experiments, <i>E. faecalis</i> can ameliorate the severity of intestinal inflammation and thereby protect mice from dextran sodium sulfate (DSS)-induced colitis and the formation of CRC in wild type mice.On the other hand, <i>E. faecalis</i> cannot prevent DSS-induced colitis in NLRP3 knockout mice.
|
30823406 |
2019 |
|
Colitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In present study, we evaluated the effect of palmatine on dextran sulfate sodium (DSS)-induced mice colitis and examined whether its effect is exerted by promoting mitophagy-mediated NLRP3 inflammasome inactivation.
|
30496979 |
2019 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We also found that IRGM suppresses NLRP3-mediated exacerbated outcomes of dextran sodium sulfate (DSS)-induced colitis in a mouse model.
|
31177914 |
2019 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Evodiamine prevents dextran sulfate sodium-induced murine experimental colitis via the regulation of NF-κB and NLRP3 inflammasome.
|
30554117 |
2019 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, the NLRP3 inflammasome is a key player in the pathogenesis of dextran sulfate sodium (DSS)-induced colitis.
|
31026586 |
2019 |
|
Colitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Exaggerated NLRP3 and IL-1β expression in <i>Vsig4<sup>-/-</sup></i> mice is accountable for deleterious disease severity in experimental autoimmune encephalomyelitis (EAE) and resistance to dextran sulfate sodium (DSS)-induced colitis.
|
30662948 |
2019 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
PAP-1 ameliorates DSS-induced colitis with involvement of NLRP3 inflammasome pathway.
|
31351364 |
2019 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, our research describes a mechanism by which KA/GPR35 signaling represses adaptive NLRP3 inflammasome activation to increase colitis susceptibility and suggests a potential metabolic target for the intervention of stress-related colonic disorder.
|
30790702 |
2019 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Polysaccharide from Scutellaria baicalensis Georgi ameliorates colitis via suppressing NF-κB signaling and NLRP3 inflammasome activation.
|
30936012 |
2019 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
NLRP3 inflammasome has been reported to be associated with inflammatory bowel disease including colitis due to its potential ability to induce IL-1β secretion.
|
30901677 |
2019 |
|
Colitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, the protection of VI-16 against DSS-induced colitis was dependent on NLRP3 expression in hematopoietic cells.
|
31152156 |
2019 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results indicate that CA could ameliorate DSS-induced colitis through inhibition of NLRP3 inflammasome activation and miR-21 and miR-155 levels in colons and macrophage, suggesting that CA might be a potentially effective drug for UC.
|
30530166 |
2019 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
One inflammasome in particular, NLRP3, has been analysed extensively in its contribution to colitis and has been shown to be associated with the development of colitis-associated colorectal cancer.
|
30206651 |
2018 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ginsenoside Rd ameliorates colitis by inducing p62-driven mitophagy-mediated NLRP3 inflammasome inactivation in mice.
|
30012462 |
2018 |
|
Colitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis.
|
30315268 |
2018 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transcriptomic analysis reveals a controlling mechanism for NLRP3 and IL-17A in dextran sulfate sodium (DSS)-induced colitis.
|
30297787 |
2018 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Brusatol ameliorates 2, 4, 6-trinitrobenzenesulfonic acid-induced experimental colitis in rats: Involvement of NF-κB pathway and NLRP3 inflammasome.
|
30218953 |
2018 |
|
Colitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together, cardamonin ameliorated colitis in mice through the activation of AhR/Nrf2/NQO1 pathway and consequent inhibition of NLRP3 inflammasome activation.
|
30071202 |
2018 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study was to examine the effect of NOR on colitis and the underlying mechanism related to NLRP3 inflammasome activation.
|
29576052 |
2018 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study was to investigate the protective effects of curcumin on dextran sulfate sodium (DSS)-induced colitis through inhibiting NLRP3 inflammasome activation and IL-1β production.
|
30396035 |
2018 |
|
Colitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results indicate that TRAIL reduces the induction of colitis and the initiation of CAC by inhibiting pro-inflammatory signaling and promoting tissue repair to maintain intestinal homeostasis through activation of the NLRP3 inflammasome.
|
29416724 |
2018 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, we investigated the therapeutic effects of CAI in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced rat colitis and the involvement of CAI action with NLRP3 inflammasome and NF-κB pathway.
|
28152446 |
2017 |
|
Colitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
NLRP3 inflammasome activity in IL-10-/- mice was elevated prior to colitis onset; it progressively increased as disease worsened and peaked as macroscopic disease emerged.
|
27993998 |
2017 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the anti-inflammatory effect of Huaier in dextran sulfate sodium (DSS)-induced murine colitis and revealed the underlying mechanisms by targeting NLRP3 inflammasomes.
|
28380426 |
2017 |
|
Colitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We suggest that hypoxia counteracts inflammation through the downregulation of the binding of mTOR and NLRP3 and activation of autophagy.Hypoxia and HIF-1α activation are protective in mouse models of colitis, and the latter regulates autophagy.Here Cosin-Roger et al. show that hypoxia ameliorates intestinal inflammation in Crohn's patients and murine colitis models by inhibiting mTOR/NLRP3 pathway and promoting autophagy.
|
28740109 |
2017 |