|
Kidney Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Phloretin could effectively attenuate UA-induced renal injury via co-inhibiting NLRP3 and UA reabsorption, and thus it might be a potential therapy to hyperuricemia-related renal diseases.
|
31790902 |
2020 |
|
Kidney Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
The canonical NLRP3-ASC-caspase-1-IL-1β-IL-18 axis has been shown to contribute to the pathophysiology of several kidney diseases by regulating renal necroinflammation.
|
30922667 |
2019 |
|
Kidney Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
We proposed that the silicon exposure could be related to his kidney disease in the patient and NLRP3 mediated inflammation might be involved in its pathogenesis which needs further explorations.
|
31809666 |
2019 |
|
Kidney Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Furthermore, we highlight the possibility of modifying the NLRP3-dependent inflammasome as a new and complementary therapeutic strategy to treat this severe and devastating kidney disease.
|
30169827 |
2019 |
|
Kidney Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Moreover, findings in experimental models of kidney disease suggest that small-molecule inhibitors targeting NLRP3 and other inflammasome components are promising therapeutic agents.
|
31164720 |
2019 |
|
Kidney Diseases
|
0.200 |
AlteredExpression
|
group |
BEFREE |
Overall, our findings demonstrated that ZIKV infection induced AKI by activating NLRP3 inflammasome and apoptosis through suppressing Bcl-2 expression, which provided potential therapeutic targets for ZIKV-associated renal diseases.
|
31474993 |
2019 |
|
Kidney Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
The NLRP3 inflammasome plays an important role in mediating podocyte injury in various kidney diseases.
|
31796125 |
2019 |
|
Kidney Diseases
|
0.200 |
AlteredExpression
|
group |
BEFREE |
Furthermore, IL-22 largely inhibited renal activation of NLRP3 inflammasome in AA-induced nephropathy.
|
31616439 |
2019 |
|
Kidney Diseases
|
0.200 |
AlteredExpression
|
group |
BEFREE |
TEA suppressed NLRP3 inflammasomes via inhibition of ERK1/2 signal transduction; decreased proteinuria and attenuated renal tubule lesions; and inhibited the expression of NLRP3 in tubules in rats with Adriamycin nephropathy.
|
31191310 |
2019 |
|
Kidney Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
The Nucleotide binding and oligomerization domain-like receptorfamily pyrin domain-containing 3 (NLRP3)-inflammasome plays an important role in various diseases, including a variety of kidney diseases.
|
29929501 |
2018 |
|
Kidney Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
NLRP3 inflammasome activation was shown in our rat model of doxorubicin nephropathy.
|
29913457 |
2018 |
|
Kidney Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
The NLR family pyrin domain-containing 3 (NLRP3) inflammasome has been shown to play a pivotal role in inflammation in a mouse kidney disease model.
|
28821730 |
2017 |
|
Kidney Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
However, the role of NLRP3 in human renal disease is completely unknown.
|
27819323 |
2016 |
|
Kidney Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Nod-like receptor pyrin domain-containing-3 (NLRP3) has been implicated in the pathogenesis of experimental renal injury, yet its characterization in human kidney disease remains largely unexplored.
|
27093923 |
2016 |
|
Kidney Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
TLRs, NLRs and NLRP3, therefore, have become promising drug targets to enable specific modulation of kidney inflammation and suppression of immunopathology in kidney disease.
|
24890433 |
2014 |
|
Kidney Diseases
|
0.200 |
AlteredExpression
|
group |
BEFREE |
Protein and mRNA expression of P2X7 R, NLRP3, and ASC were also increased in kidneys from subjects with type 2 diabetes and the metabolic syndrome, showing histologically documented renal disease.
|
23843215 |
2013 |
|
Kidney Diseases
|
0.200 |
AlteredExpression
|
group |
BEFREE |
In tissue from human renal biopsies, a wide variety of nondiabetic kidney diseases exhibited increased expression of NLRP3 mRNA, which correlated with renal function.
|
20688930 |
2010 |
|
Kidney Diseases
|
0.200 |
Biomarker
|
group |
HPO |
|
|
|