NLRP3, NLR family pyrin domain containing 3, 114548

N. diseases: 805; N. variants: 74
Disease: Pneumococcal Infections ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0032269
Disease: Pneumococcal Infections
Pneumococcal Infections 		0.050 Biomarker group BEFREE Downregulation of FSTL‑1 attenuates the inflammation injury during Streptococcus pneumoniae infection by inhibiting the NLRP3 and TLR4/NF‑κB signaling pathway. 31638229 2019
CUI: C0032269
Disease: Pneumococcal Infections
Pneumococcal Infections 		0.050 AlteredExpression group BEFREE NLRP3/ASC/Caspase-1 axis and serine protease activity are involved in neutrophil IL-1β processing during Streptococcus pneumoniae infection. 30982580 2019
CUI: C0032269
Disease: Pneumococcal Infections
Pneumococcal Infections 		0.050 Biomarker group BEFREE NLRP3 inflammasome activation in aged macrophages is diminished during Streptococcus pneumoniae infection. 29097427 2018
CUI: C0032269
Disease: Pneumococcal Infections
Pneumococcal Infections 		0.050 AlteredExpression group BEFREE Decreased NLRP3 inflammasome expression in aged lung may contribute to increased susceptibility to secondary Streptococcus pneumoniae infection. 29203400 2018
CUI: C0032269
Disease: Pneumococcal Infections
Pneumococcal Infections 		0.050 Biomarker group BEFREE Furthermore, Nox4-deficient mice showed substantial reduction in caspase-1 activation and in interleukin (IL)-1β and IL-18 production, and there was improved survival in a mouse model of NLRP3-mediated Streptococcus pneumoniae infection. 27455510 2016