Pneumonia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The innate immunity NOD-like receptor 3 (NLRP3) inflammasome exerts critical function against pneumonia caused by A. baumannii infection, however, the role of Omp34 in the activation of the NLRP3 inflammasome and its corresponding regulatory mechanism are not clearly elucidated.
|
30439507 |
2020 |
Pneumonia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Polydatin suppresses the development of lung inflammation and fibrosis by inhibiting activation of the NACHT domain-, leucine-rich repeat-, and pyd-containing protein 3 inflammasome and the nuclear factor-κB pathway after Mycoplasma pneumoniae infection.
|
30548648 |
2019 |
Pneumonia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mechanistically, we show that TREM-1 activation alleviates lung inflammation and improves alveolarization through downregulating RIPK3-mediated necroptosis and NLRP3 (nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3) inflammasome activation in hyperoxia-exposed neonatal mice.
|
30281332 |
2019 |
Pneumonia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Notably, administration of NLRP3 inhibitors in asthma models restrains AHR and pulmonary inflammation.
|
31590215 |
2019 |
Pneumonia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, restoration of intracellular miR-223/142 via vesicle-mediated delivery suppresses macrophage activation and lung inflammation via inhibition of Nlrp3 inflammasome activation.
|
31331947 |
2019 |
Pneumonia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results from present study demonstrate that compound 4c protects pneumocystis carinii induced pneumonia through suppression of inflammatory cytokines and NLRP3 activation.
|
31002962 |
2019 |
Pneumonia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Acute lung injury(ALI) can trigger persistent lung inflammation and fibrosis through activation of the NLRP3 inflammasome and subsequent secretion of mature IL-1β, suggesting that the NLRP3 inflammasome is a potential therapeutic target for ALI, for which new therapeutic approaches are needed.
|
29783158 |
2018 |
Pneumonia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, SOCS-1 relieves smoke inhalation-induced pulmonary inflammation and injury by inhibiting NALP3 inflammasome formation.
|
29907905 |
2018 |
Pneumonia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, consisting of NLRP3, ASC (the adaptor apoptosis-associated speck-like protein containing a CARD) and caspase-1, has been implicated in protective immunity during pneumonia induced by high doses of S. pneumoniae serotype 2.
|
28971472 |
2018 |
Pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
AT activates the NLRP3 inflammasome; deletion of Nlrp3, or AT neutralization, protects mice from lethal S. aureus pneumonia.
|
29490278 |
2018 |
Pneumonia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated the role of NLRP3 inflammasome in fungi-induced allergic lung inflammation and examined the regulatory mechanism of NLRP3 inflammasome, focusing on PI3K-δ in airway epithelium.
|
29622694 |
2018 |
Pneumonia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Deletion of Kcnk6 (encoding TWIK2) prevented NLRP3 activation in macrophages and suppressed sepsis-induced lung inflammation.
|
29958799 |
2018 |
Pneumonia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We examined the importance of mtROS and NLRP3 inflammasome and their interactions in multiple ozone-induced lung inflammation and emphysema.
|
30466433 |
2018 |
Pneumonia
|
0.100 |
Biomarker
|
disease |
BEFREE |
NLRP3 inflammasome mediates interleukin-1β production in immune cells in response to Acinetobacter baumannii and contributes to pulmonary inflammation in mice.
|
28032341 |
2017 |
Pneumonia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results demonstrated that resveratrol significantly alleviates <i>S. aureus</i> pneumonia in mice, the possible underlying mechanism of which is associated with the inhibition of the NLRP3 inflammasome.
|
29285164 |
2017 |
Pneumonia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The NLRP3 inflammasome plays a pivotal role in the development of lung inflammation.
|
28870124 |
2017 |
Pneumonia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have found that PB1-F2 derived from H7N9 activates the NLRP3 inflammasome and induces lung inflammation and cellular recruitment that is NLRP3-dependent.
|
27913620 |
2017 |
Pneumonia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Uric acid released from injured tissue is considered a major endogenous danger signal and local instillation of uric acid crystals induces acute lung inflammation via activation of the NLRP3 inflammasome.
|
23226314 |
2012 |
Pneumonia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We further found that NLRP3 was beneficial for mice during pneumonia caused by pneumococci expressing hemolytic pneumolysin and was involved in cytokine production and maintenance of the pulmonary microvascular barrier.
|
21646297 |
2011 |