|
Pneumonitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mechanistically, we show that TREM-1 activation alleviates lung inflammation and improves alveolarization through downregulating RIPK3-mediated necroptosis and NLRP3 (nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3) inflammasome activation in hyperoxia-exposed neonatal mice.
|
30281332 |
2019 |
|
Pneumonitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, restoration of intracellular miR-223/142 via vesicle-mediated delivery suppresses macrophage activation and lung inflammation via inhibition of Nlrp3 inflammasome activation.
|
31331947 |
2019 |
|
Pneumonitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Notably, administration of NLRP3 inhibitors in asthma models restrains AHR and pulmonary inflammation.
|
31590215 |
2019 |
|
Pneumonitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Polydatin suppresses the development of lung inflammation and fibrosis by inhibiting activation of the NACHT domain-, leucine-rich repeat-, and pyd-containing protein 3 inflammasome and the nuclear factor-κB pathway after Mycoplasma pneumoniae infection.
|
30548648 |
2019 |
|
Pneumonitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Deletion of Kcnk6 (encoding TWIK2) prevented NLRP3 activation in macrophages and suppressed sepsis-induced lung inflammation.
|
29958799 |
2018 |
|
Pneumonitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pretreatment of aged mice with endoplasmic reticulum chaperone and the stress-reducing agent tauroursodeoxycholic acid (TUDCA) decreased mortality in aged hosts that was associated with increased NLRP3 inflammasome activation, improved pathogen clearance, and decreased pneumonitis during infection.
|
29097427 |
2018 |
|
Pneumonitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated the role of NLRP3 inflammasome in fungi-induced allergic lung inflammation and examined the regulatory mechanism of NLRP3 inflammasome, focusing on PI3K-δ in airway epithelium.
|
29622694 |
2018 |
|
Pneumonitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, SOCS-1 relieves smoke inhalation-induced pulmonary inflammation and injury by inhibiting NALP3 inflammasome formation.
|
29907905 |
2018 |
|
Pneumonitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We examined the importance of mtROS and NLRP3 inflammasome and their interactions in multiple ozone-induced lung inflammation and emphysema.
|
30466433 |
2018 |
|
Pneumonitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Acute lung injury(ALI) can trigger persistent lung inflammation and fibrosis through activation of the NLRP3 inflammasome and subsequent secretion of mature IL-1β, suggesting that the NLRP3 inflammasome is a potential therapeutic target for ALI, for which new therapeutic approaches are needed.
|
29783158 |
2018 |
|
Pneumonitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have found that PB1-F2 derived from H7N9 activates the NLRP3 inflammasome and induces lung inflammation and cellular recruitment that is NLRP3-dependent.
|
27913620 |
2017 |
|
Pneumonitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The NLRP3 inflammasome plays a pivotal role in the development of lung inflammation.
|
28870124 |
2017 |
|
Pneumonitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
NLRP3 inflammasome mediates interleukin-1β production in immune cells in response to Acinetobacter baumannii and contributes to pulmonary inflammation in mice.
|
28032341 |
2017 |
|
Pneumonitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Uric acid released from injured tissue is considered a major endogenous danger signal and local instillation of uric acid crystals induces acute lung inflammation via activation of the NLRP3 inflammasome.
|
23226314 |
2012 |