|
Tuberculosis
|
0.380 |
Biomarker
|
disease |
CTD_human |
A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis.
|
17322885 |
2007 |
|
Tuberculosis
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Coinheritance of these polymorphisms with previously identified risk alleles in Toll-like receptor 2 and TIRAP was associated with an additive risk of tuberculosis susceptibility.
|
22223854 |
2012 |
|
Tuberculosis
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
These results support the influence of TIRAP (MAL) S180L polymorphism on TB and indicate that TB and SLE might share a common immunogenetic pathway in the innate immune response.
|
18417424 |
2008 |
|
Tuberculosis
|
0.380 |
GeneticVariation
|
disease |
LHGDN |
Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations.
|
18305471 |
2008 |
|
Tuberculosis
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in TIRAP do not appear to be involved in childhood TB susceptibility in South Africa, but may play a role in determining occurrence of TBM.
|
19693265 |
2009 |
|
Tuberculosis
|
0.380 |
GeneticVariation
|
disease |
LHGDN |
These results support the influence of TIRAP (MAL) S180L polymorphism on TB and indicate that TB and SLE might share a common immunogenetic pathway in the innate immune response.
|
18417424 |
2008 |
|
Tuberculosis
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
We investigated all the single-nucleotide polymorphisms (SNPs) within the TIRAP exon 5 in a case-control study of 212 patients with tuberculosis and 215 controls in a Chinese population.
|
21218381 |
2011 |
|
Tuberculosis
|
0.380 |
Biomarker
|
disease |
BEFREE |
To test common and rare TLR variants involved in susceptibility or resistance to infection with Mycobacterium tuberculosis we screened the exons of the genes encoding TLR 1, 2, 4, and the adaptor molecule TIRAP in more than 4500 tuberculosis (TB) cases and controls from Ghana.
|
27214039 |
2016 |
|
Tuberculosis
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate the relationship of <i>TLR1, TLR6, MYD88</i> and <i>TIRAP</i> polymorphisms with susceptibility to latent tuberculosis infection (LTBI) and tuberculosis (TB).
|
30963003 |
2019 |
|
Tuberculosis
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Humans that are heterozygous for the common S180L polymorphism in the Toll-like receptor (TLR) adaptor Mal (encoded by TIRAP) are protected from a number of infectious diseases, including tuberculosis (TB), whereas those homozygous for the allele are at increased risk.
|
26885859 |
2016 |
|
Malaria
|
0.330 |
Biomarker
|
disease |
CTD_human |
A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis.
|
17322885 |
2007 |
|
Malaria
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
MyD88-adaptor-like/TIR domain containing adaptor protein polymorphism for single nucleotide polymorphism rs8177374 is related with the susceptibility of malaria.
|
28482182 |
2017 |
|
Malaria
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
A mutation (S180L) in the TLR downstream signal transducer TIRAP has recently been reported to be common in Europeans and Africans and to roughly half the risks of heterogeneous infectious diseases including malaria, tuberculosis, bacteremia, and invasive pneumococal disease in heterozygous mutation carriers.
|
19602285 |
2009 |
|
Malaria
|
0.330 |
Biomarker
|
disease |
BEFREE |
Genetic polymorphisms (SNPs) in different TLRs, TIRAP, and CD14 were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis in 325 patients infected with P. vivax and 274 healthy individuals without malaria history in the prior 12 months from the same endemic area.Parasite load was determined by qPCR.
|
28850598 |
2017 |
|
Bacteremia
|
0.300 |
Biomarker
|
disease |
CTD_human |
A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis.
|
17322885 |
2007 |
|
Malignant neoplasm of prostate
|
0.300 |
Biomarker
|
disease |
CTD_human |
The interaction of four genes in the inflammation pathway significantly predicts prostate cancer risk.
|
16284379 |
2005 |
|
MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO (finding)
|
0.300 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Invasive Pneumococcal Disease, Recurrent Isolated, 1
|
0.300 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Septicemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts.
|
20525286 |
2010 |
|
Septicemia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Remarkably, homozygous TIRAP 180L tend to increase the risk of sepsis in the German study (P = 0.04).
|
19602285 |
2009 |
|
Septicemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
These findings verify the ability of gefitinib to directly disrupt the interaction of TIRAP and c-Jun, thereby inhibiting a major inflammatory response that is often observed in patients experiencing sepsis.
|
30909134 |
2019 |
|
Septicemia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in the TIRAP gene are associated with increased risk of sepsis-associated acute lung injury.
|
21118491 |
2010 |
|
Sepsis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in the TIRAP gene are associated with increased risk of sepsis-associated acute lung injury.
|
21118491 |
2010 |
|
Sepsis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Remarkably, homozygous TIRAP 180L tend to increase the risk of sepsis in the German study (P = 0.04).
|
19602285 |
2009 |
|
Sepsis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts.
|
20525286 |
2010 |