|
Abscess
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
A total of 121 patients with major abscesses and 132 with DFIs participating in a randomized clinical trial were genotyped for 13 nonsynonymous single-nucleotide polymorphisms (SNPs) in genes coding for TLRs and the signaling adaptor molecule TIRAP.
|
31786695 |
2020 |
|
Acute Megakaryocytic Leukemias
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
On the basis of frequency and prognosis, AMKL can be classified to 3 risk groups: good risk-7p abnormalities; poor risk-normal karyotypes, -7, 9p abnormalities including t(9;11)(p22;q23)/MLL-MLLT3, -13/13q-, and -15; and intermediate risk-others including t(1;22)(p13;q13)/OTT-MAL (RBM15-MKL1) and 11q23/MLL except t(9;11).
|
26215111 |
2015 |
|
Adult Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
TIRAP p.R81C is a novel lymphoma risk variant which enhances cell proliferation <i>via</i> NF-κB mediated signaling in B-cells.
|
30381301 |
2019 |
|
Alopecia
|
0.010 |
Biomarker
|
disease |
BEFREE |
TIRAP S180 L showed a positive association with alopecia and malar rashes, while an inverse association with psychosis was observed.
|
25182168 |
2015 |
|
Aortic Aneurysm, Abdominal
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our aim was to investigate whether blockage of TLR signaling, under the control of TIR domain-containing adaptor protein including IFN-β (TRIF), could inhibit the inflammatory response and AAA development in mice.
|
26100679 |
2015 |
|
Asymptomatic bacteriuria
|
0.010 |
Biomarker
|
disease |
BEFREE |
We genotyped polymorphisms in CXCR1, CXCR2, TLR1, TLR2, TLR4, TLR5, and TIRAP in women with and without ASB.
|
20016852 |
2009 |
|
Autoimmune Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Our findings highlight a role for Mal outside the TLR system and imply that genetic variation in TIRAP may be linked to other IFN-γ-related diseases including autoimmunity and cancer.
|
26885859 |
2016 |
|
Bacteremia
|
0.300 |
Biomarker
|
disease |
CTD_human |
A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis.
|
17322885 |
2007 |
|
Bacterial Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
MyD88 adapter-like (Mal), also termed TIRAP, is involved in bridging MyD88 to the receptor complex for TLR-2 and TLR4 signaling in response to bacterial infection.
|
19592497 |
2009 |
|
Bacterial Vaginosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Logistic regression was used to test associations between 14 variants assayed in 6 genes (TLR1, TLR2, TLR4, TLR6, TIRAP and MyD88) and BV/intermediate flora among 192 African-American women with clinical PID from the PID Evaluation and Clinical Health (PEACH) Study.
|
24848367 |
2014 |
|
Behcet Syndrome
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
TIRAP S180L gene polymorphism, which was previously shown to be associated with BD in a Caucasian population, has been replicated in either Turkish or Italian population in our study.
|
24064014 |
2013 |
|
Behcet Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
However, TIRAP 180Leu was significantly associated with BD in UK, but not Middle Eastern, patients.
|
21705416 |
2011 |
|
Bronchopulmonary Dysplasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The TIRAP (g.2054C > T) variant was associated with BPD (P = 0.04).
|
22058078 |
2012 |
|
Candidemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thirteen mostly nonsynonymous single nucleotide polymorphisms (SNPs) in genes encoding TLRs and signaling adaptors MyD88 and Mal/TIRAP were genotyped in 338 patients (237 white, 93 African American, 8 other race) with candidemia and 351 noninfected controls (263 white, 88 African American).
|
22301633 |
2012 |
|
Cardiovascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Twenty-four genes (ADRB2, CD14, FGB, FV, HMOX1, IL1B, IL1RN, IL6, IL10, IL17A, IRAK1, MASP2, MBL, MIR608, MIF, NOD2, PCSK9, PPARG, PROC, SERPINE1, SOD2, SVEP1, TF, TIRAP, TLR1) were extracted as reported genetic variations associated with altered outcome of both sepsis and cardiovascular diseases.
|
30660782 |
2019 |
|
Chagas Cardiomyopathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Heterozygosity for the S180L variant of MAL/TIRAP, a gene expressing an adaptor protein in the Toll-like receptor pathway, is associated with lower risk of developing chronic Chagas cardiomyopathy.
|
19456234 |
2009 |
|
Childhood Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
TIRAP p.R81C is a novel lymphoma risk variant which enhances cell proliferation <i>via</i> NF-κB mediated signaling in B-cells.
|
30381301 |
2019 |
|
Chronic Chagas' disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
TLR1-I602S, TLR2-R753Q, TLR6-S249P, and MAL/TIRAP-S180L did not associate with CD or CCC.
|
22302853 |
2012 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we report frequent single-nucleotide polymorphisms (SNP) in the flagellin receptor TLR5 and the TLR downstream effector molecules MyD88 and TIRAP that are associated with altered survival in a large cohort of Caucasian patients with colorectal cancer (n = 613).
|
24154872 |
2013 |
|
Complicated malaria
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
TIRAP S180L polymorphism was typed in 347 cases of severe malaria (SM), 232 uncomplicated malaria and 150 healthy controls.
|
27166096 |
2016 |
|
Degenerative polyarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
TLR 1, 2, 3, 4, 5, 6, and 9 receptors, and myeloid differentiation primary response protein 88, Toll/interleukin receptor (TIR) domain-containing adapter protein MyD88 adapter-like, and TIR domain-containing adapter-inducing interferon/TIR-containing adapter molecule-1 adapters were analyzed in RA (n = 10) and osteoarthritis (OA; n = 5) samples using real-time polymerase chain reaction (PCR).
|
21324962 |
2011 |
|
Dengue Fever
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Functional polymorphisms in RNA recognizing toll like receptors (TLR) 3, 7, 8 and toll-interleukin-1 receptor domain containing adapter protein adapter (TIRAP) coding genes were investigated in 120 dengue cases [87 dengue fever (DF) cases and 33 dengue hemorrhagic fever (DHF) cases] and 109 healthy controls (HC) to identify their association with clinical outcomes of dengue virus infection.
|
25446400 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In this direction, we aimed to investigate the relationship among TLR4 and IRAK1, TIRAP gene variants, and type 2 diabetes and insulin resistance, and investigate how these variants affect inflammatory factors (TNF-α, IL-6, MCP-1, and IL-1β).
|
31222667 |
2019 |
|
Diabetic foot infection
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A total of 121 patients with major abscesses and 132 with DFIs participating in a randomized clinical trial were genotyped for 13 nonsynonymous single-nucleotide polymorphisms (SNPs) in genes coding for TLRs and the signaling adaptor molecule TIRAP.
|
31786695 |
2020 |
|
Exanthema
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
TIRAP S180 L showed a positive association with alopecia and malar rashes, while an inverse association with psychosis was observed.
|
25182168 |
2015 |