C1QTNF1, C1q and TNF related 1, 114897

N. diseases: 27; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.030 Biomarker disease BEFREE CTRP1 is a novel adipokine associated with T2DM in humans. 24827430 2014
CUI: C0023895
Disease: Liver diseases
Liver diseases
0.010 Biomarker group BEFREE CTRP1 in Liver Disease. 28212710 2017
CUI: C0036690
Disease: Septicemia
Septicemia
0.010 AlteredExpression disease BEFREE CTRP1 levels were significantly higher in ICU patients with sepsis. 31083558 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.010 AlteredExpression disease BEFREE CTRP1 levels were significantly higher in ICU patients with sepsis. 31083558 2019
CUI: C0008370
Disease: Cholestasis
Cholestasis
0.010 Biomarker disease BEFREE CTRP1 correlated strongly with markers of inflammatory response, renal function, liver damage and cholestasis. 31083558 2019
CUI: C0028754
Disease: Obesity
Obesity
0.020 Biomarker disease BEFREE As CTRP1 was highly expressed in obese subjects as well as up-regulated in hypertensive patients, CTRP1 may be a newly identified molecular link between obesity and hypertension. 18171693 2008
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.020 Biomarker group BEFREE As CTRP1 was highly expressed in obese subjects as well as up-regulated in hypertensive patients, CTRP1 may be a newly identified molecular link between obesity and hypertension. 18171693 2008
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.020 AlteredExpression group LHGDN As CTRP1 was highly expressed in obese subjects as well as up-regulated in hypertensive patients, CTRP1 may be a newly identified molecular link between obesity and hypertension. 18171693 2008
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.010 AlteredExpression disease BEFREE Association of C1q/TNF-related protein-1 (CTRP1) serum levels with coronary artery disease. 31081425 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.010 AlteredExpression disease BEFREE Association of C1q/TNF-related protein-1 (CTRP1) serum levels with coronary artery disease. 31081425 2019
CUI: C0400966
Disease: Non-alcoholic Fatty Liver Disease
Non-alcoholic Fatty Liver Disease
0.020 AlteredExpression disease BEFREE At baseline, obesity, the metabolic syndrome, type 2 diabetes, and non-alcoholic fatty liver disease were significantly associated with increased CTRP1 (all p-values ≤0.001). 31051410 2019
CUI: C0028754
Disease: Obesity
Obesity
0.020 Biomarker disease BEFREE C1q/tumour necrosis factor-related protein 1 (CTRP1) is a new adipokine with multiple vascular and metabolic effects and may modulate the association between obesity and vascular diseases. 31198543 2019
CUI: C0042373
Disease: Vascular Diseases
Vascular Diseases
0.010 Biomarker group BEFREE C1q/tumour necrosis factor-related protein 1 (CTRP1) is a new adipokine with multiple vascular and metabolic effects and may modulate the association between obesity and vascular diseases. 31198543 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.030 Biomarker disease BEFREE C1qTNF-related protein 1 (CTRP1) is independently associated with type 2 diabetes. 28674284 2017
Pre-existing diabetes mellitus, non-insulin-dependent
0.010 Biomarker disease BEFREE Elevated CTRP1 Plasma Concentration Is Associated with Sepsis and Pre-Existing Type 2 Diabetes Mellitus in Critically Ill Patients. 31083558 2019
CUI: C0026691
Disease: Mucocutaneous Lymph Node Syndrome
Mucocutaneous Lymph Node Syndrome
0.010 AlteredExpression disease BEFREE Furthermore, serum CTRP1 levels were positively correlated with the time point of intravenous immunoglobulin (IVIG), WBC, N%, TNF-α, IL-1β, and IL-6 levels in the KD-CAL group.ConclusionCTRP1 may participate in the process of vasculitis and blood coagulation during the acute phase of KD. 29360808 2018
CUI: C0042384
Disease: Vasculitis
Vasculitis
0.010 AlteredExpression disease BEFREE Furthermore, serum CTRP1 levels were positively correlated with the time point of intravenous immunoglobulin (IVIG), WBC, N%, TNF-α, IL-1β, and IL-6 levels in the KD-CAL group.ConclusionCTRP1 may participate in the process of vasculitis and blood coagulation during the acute phase of KD. 29360808 2018
CUI: C0400966
Disease: Non-alcoholic Fatty Liver Disease
Non-alcoholic Fatty Liver Disease
0.020 Biomarker disease BEFREE Hence, various roles in metabolic pathways can link CTRP1 to NAFLD pathogenesis. 28212710 2017
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.010 AlteredExpression group BEFREE High CTRP1 levels may have a renal protective role since they were associated with slower kidney disease progression. 31198543 2019
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.010 Biomarker disease BEFREE Identification of CTRP1 as a Prognostic Biomarker and Oncogene in Human Glioblastoma. 31183364 2019
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.010 Biomarker disease BEFREE Identification of CTRP1 as a Prognostic Biomarker and Oncogene in Human Glioblastoma. 31183364 2019
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.010 Biomarker disease BEFREE Inhibition of CTRP1 may inhibit the pathogenesis of atherosclerosis at early stage. 28625919 2017
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.010 Biomarker disease BEFREE Inhibition of CTRP1 may inhibit the pathogenesis of atherosclerosis at early stage. 28625919 2017
CUI: C0011175
Disease: Dehydration
Dehydration
0.020 Biomarker phenotype BEFREE Mice lacking Ctrp1 fail to maintain normotension under dehydration conditions, resulting in hypotension, suggesting that CTRP1 is an essential protein for maintaining blood pressure homeostasis. 30463644 2018
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.010 AlteredExpression phenotype BEFREE Moreover, CTRP1 knockdown inhibited CCL2 expression, and CCL2 overexpression reversed the inhibition of cell proliferation and migration induced by CTRP1 knockdown, suggesting that CTRP1 promoted tumor progression by regulating CCL2 expression. 31183364 2019