CIRBP, cold inducible RNA binding protein, 1153

N. diseases: 72; N. variants: 0
Disease: Hypertensive disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.010 Biomarker group BEFREE Based on the existing reports and our unpublished data, we conclude that the cross talk between [ROS]<sub>mito</sub> and [Ca<sup>2+</sup>]<sub>i</sub>, that is RISP-dependent mitochondrial ROS-induced RyR2-mediated SR Ca<sup>2+</sup> release (ROS-induced Ca<sup>2+</sup> release, RICR) and RyR2-mediated SR Ca<sup>2+</sup> release-induced RISP-dependent mitochondrial ROS production (Ca<sup>2+</sup>-induced ROS production, CIRP), may form a positive reciprocal loop in mediating HPV and also possibly pulmonary hypertension. 29047093 2017