|
Retinoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Retinoblastoma (Rb) downregulation by HPV E7 results in p16 upregulation.
|
16401683 |
2006 |
|
Retinoblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Alterations of the retinoblastoma and p16 pathway correlate with promoter methylation in malignant fibrous histiocytomas.
|
17094467 |
2006 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although the underlying molecular-genetic pathways are not yet fully understood, the current results suggest functional reduction of the tumor suppressor genes Rb and p16 to be associated with progression of bladder cancer to a more malignant and aggressive behaviour.
|
15161057 |
2004 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
At least 1 of these abnormalities was found in 86% of the cases and a positive correlation was noted between p16 and pRb (P = 0.009).
|
18484097 |
2008 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
At present, the most useful methods of risk assessment are those performed on the following genes: BRCA1 and BRCA2 especially for hereditary breast and ovarian cancer, hMLH1 and hMSH2 for hereditary non polyposis colorectal cancer, APC for familial adenomatous polyposis, ret for medullary thyroid carcinoma, p53 for the Li-Fraumeni syndrome, p16 for melanoma and RB1 for retinoblastoma.
|
11205230 |
2001 |
|
Retinoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Coexisting intraepithelial carcinoma was detected in seven NECs and only one lesion showed the combination of diffuse RB loss and p16 overexpression.
|
30952735 |
2019 |
|
Retinoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Gene and protein transfer experiments demonstrated that concurrent alterations of cyclin D1 and p16 levels cooperate to (de)regulate G1 control in diploid fibroblasts, and that both events influence growth of retinoblastoma (RB)-positive, but not RB-deficient cancer cells.
|
7585513 |
1995 |
|
Retinoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Genes most commonly associated with the process of oncogenesis include: p53 inactivating mutation; hDM2 overexpression; p16 reduced expression; K-/H-RAS activating mutation; PTEN inactivating mutation/deletion; EGFR activating mutation and overexpression; retinoblastoma inactivating mutation and deletion; Cyclin proteins overexpression; CD95 reduced expression; protective BCL-2 proteins overexpression; to name but just a few of such molecules.
|
23974512 |
2013 |
|
Retinoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Head and neck HPV-NEC is a rare, aggressive entity that can show mixed small and large cell features and p16 upregulation; p53 and Rb are variable with limited diagnostic utility.
|
30475447 |
2019 |
|
Retinoblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Immortal HUCs and bladder cancer cell lines show either alteration of p16 or pRb, the product of the retinoblastoma (RB) TSG.
|
9436977 |
1998 |
|
Retinoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, recent knock-out mouse studies implicated PPM1D in the regulation of p16 expression and the RB tumour suppressor pathway.
|
16254685 |
2006 |
|
Retinoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, the expression of RB and p16 protein was examined by Western blot analysis.
|
8674005 |
1996 |
|
Retinoblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, we report for the first time that resistance of KRAS-mutant NSCLCs to MEK inhibitor is, at least partly, due to p16 mutation status, and we described a drug combination that efficiently reactivates the RB tumor suppressor pathway to trigger radiosensitizing effects, apoptosis, and cell-cycle arrest.
|
26728409 |
2016 |
|
Retinoblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In familial cutaneous malignant melanoma (CMM), disruption of the retinoblastoma (pRB) pathway frequently occurs through inactivating mutations in the p16 (p16INK4A/CDKN2A/MTS1) gene or activating mutations in the G1-specific cyclin dependent kinase 4 gene (CDK4).
|
10732752 |
2000 |
|
Retinoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the TBP-2-overexpressing cells, a G1 arrest was observed in association with an increase of p16 expression and reduction of retinoblastoma phosphorylation.
|
14983878 |
2004 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this phase II trial, patients with metastatic platinum-refractory UC molecularly selected for p16 loss and intact Rb by tumour immunohistochemistry received palbociclib 125 mg p.o. daily for 21 days of a 28-day cycle.
|
30293995 |
2018 |
|
Retinoblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data indicate that in spite of low or absent p16 expression, genetic alterations of the p16 and Rb tumour suppressor genes are rare in endometrial carcinogenesis.
|
10071231 |
1999 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Paraffin sections of 9 reactive lymph nodes and 43 low-grade and 60 high-grade malignant lymphomas were reacted with antibodies against pRB and p16.
|
9620022 |
1998 |
|
Retinoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Previously, we reported that loss of p16 expression rather than loss of Rb occurs in most human pituitary adenomas.
|
9290697 |
1997 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Several molecules such as retinoblastoma and p16 were raised as key factors in tumorigenesis and invasiveness.
|
21565925 |
2011 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Strong immunoreactivity for p16 protein was observed in both nuclei and cytoplasm of the tumor cells in eight out of nine cases of eccrine porocarcinomas, while RB expression was negative in these cases.
|
12207741 |
2002 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Studies on Radiation Therapy Oncology Group tissue samples have identified aberrant expression of p53, MDM2 (an E3 ubiquitin ligase that targets p53 for proteosomal degradation), and p16 (an upstream regulator of retinoblastoma and hence E2F1 in prostate cancer); abnormal expression of these biomarkers has been associated with clinical outcome after radiotherapy ± androgen deprivation therapy.
|
20832018 |
2010 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The p16 gene expresses two alternative transcripts (p16alpha and p16beta) involved in tumor suppression via the retinoblastoma (Rb) or p53 pathways.
|
10498902 |
1999 |
|
Retinoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The p16 protein transcriptionally inhibits expression of retinoblastoma tumor-suppressor gene pRB.
|
11792751 |
2002 |
|
Retinoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The p16 gene regulates cyclin D1-CDK4 activity and prevents retinoblastoma tumor suppressor gene phosphorylation, thereby downregulating cellular proliferation.
|
12148857 |
2002 |