|
Acral Lentiginous Malignant Melanoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Acral Spitz nevi were characterized by strong and diffuse P16 and P21 expression, which differs from acral nevi and acral lentiginous melanoma.
|
29537991 |
2018 |
|
Acral Lentiginous Malignant Melanoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Loss of expression of p16 is associated with lower levels of CD3+ and CD8+ TIL, indicating a probable relationship between p16 and TIL immune response in ALM .
|
30778854 |
2019 |
|
Acromegaly
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
However, the expression of the p16 protein was lower than in the NFA group than in the CD and acromegaly groups (p = 0.030, p = 0.033, respectively), and E2F1 protein expression was significantly higher in the NFA group than in the CD group (p = 0.025). p73 protein expression in patients with acromegaly was significantly higher (p = 0.031) than that in the CD group.
|
31828584 |
2020 |
|
ACTH-Secreting Pituitary Adenoma
|
0.020 |
PosttranslationalModification
|
disease |
BEFREE |
Tissue from 31 corticotroph adenomas and 16 nonadenomatous pituitaries were subject to methylation-sensitive PCR to determine the methylation status of the p16 gene CpG island.
|
15014032 |
2004 |
|
ACTH-Secreting Pituitary Adenoma
|
0.020 |
PosttranslationalModification
|
disease |
BEFREE |
The mechanisms of p16 down-regulation probably involve CDKN2A methylation in most types, but remain to be determined in somatotroph and corticotroph adenomas.
|
11276008 |
2001 |
|
Actinic keratosis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Finally, the absence of differences in p53 and p16 expressions is at variance with other epithelia where the classical pathway is associated with human papillomavirus infection and can be explained by the fact that both AK pathways share identical mechanisms of actinic oncogenesis.
|
28796927 |
2018 |
|
Actinic keratosis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The aims of this study were to assess (1) the relation between risk factors for carcinogenesis, sun exposure and immune status, and p16 or p53 expression, and (2) to assess differences in p16 and p53 expression between KINs and SCCs.
|
13679450 |
2003 |
|
Actinic keratosis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Six different mutations (12%) were detected in exon 2 of p16 (common to p16alpha and p16beta), in five out of 21 squamous lesions (24%) (one AK and four SCCs) and one out of 28 BCCs (3.5%).
|
10498902 |
1999 |
|
Acute leukemia
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
These data show that inactivation of either the p15 or p16 gene by point mutation is a very uncommon event in acute leukaemias.
|
8616035 |
1996 |
|
Acute leukemia
|
0.060 |
PosttranslationalModification
|
disease |
BEFREE |
These results suggest that inactivation of p16 and p15 genes is one of the most common genetic events in acute leukemia, and plays an important role for the RB/p16 pathway in the pathogenesis of acute leukemia.
|
10634644 |
2000 |
|
Acute leukemia
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
With the successful application of bio-cell chip technique, we found that the deletion of p16 contributed to the oncogenesis in acute leukemia, but not in chronic leukemia.
|
16949174 |
2007 |
|
Acute leukemia
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that alterations of p16 and p15 genes are involved in a subset of acute leukemias with MLL gene rearrangement not only of lymphoid but also of myeloid phenotype.
|
9447829 |
1997 |
|
Acute leukemia
|
0.060 |
PosttranslationalModification
|
disease |
BEFREE |
In this study, the authors investigated the frequency and prognostic significance of p15 and p16 gene methylation in adult acute leukemia.
|
11413509 |
2001 |
|
Acute leukemia
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Reports on homozygous deletion of p16 and p15 genes suggest the value of larger, prospective studies with standardized treatment protocols to definitively establish the prognostic utility of p15/p16 deletions in acute leukemias.
|
10073286 |
1999 |
|
Acute lymphocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We identified homozygous deletion of p16 and p15 genes in five (19%) of 27 acute lymphoblastic leukemias (ALLs) and in two (11%) of 19 acute myeloid leukemias (AMLs).
|
9447829 |
1997 |
|
Acute lymphocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A lesser proportion of the p16 deletion in T-ALL patients was observed, probably related to the low prevalence of this subtype in our population.
|
18617057 |
2008 |
|
Acute lymphocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Single stranded conformation polymorphism analysis of exons 1 and 2 of the p16 gene was performed in 88 cases of ALL, including the 63 patients analyzed by Southern blot.
|
7833469 |
1995 |
|
Acute lymphocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The prevalence of p16 deletion was 39.7% in B-lineage ALL and 33.3% in T-lineage ALL.
|
27967319 |
2017 |
|
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data indicate that p16 gene is deleted in a higher frequency than type I interferon genes in ALL.
|
9922477 |
1998 |
|
Acute lymphocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Six of 12 cell lines, including acute lymphoblastic leukemia (ALL) lines of T-cell (three of four), of precursor-B cell (two of four) and of mixed phenotype (one of four), showed homozygous deletion of the p16 gene using PCR and Southern blotting.
|
8668350 |
1996 |
|
Acute lymphocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We analyzed 60 B precursor acute lymphoblastic leukemia (ALL) primary samples and 15 cell lines for homozygous deletions of p16 and p15 genes and mutations of p16 gene.
|
8683987 |
1996 |
|
Acute lymphocytic leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Collectively, our results suggest that losses of p15 and/or p16 gene expression result in elevated levels of DHFR in BP-ALL in children.
|
11380466 |
2001 |
|
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, 25 paediatric patients with ALL were analysed at diagnosis and relapse for their p16 (exon 2) status using the most accurate method of detection, real-time polymerase chain reaction (PCR).
|
11380395 |
2001 |
|
Acute lymphocytic leukemia
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
The methylation-specific polymerase chain reaction (MS-PCR) was used to analyze p15 and p16 gene methylation in 49 cases of acute lymphoblastic leukemia (ALL) and 29 cases of acute myelogenous leukemia (AML).
|
11413509 |
2001 |
|
Acute lymphocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results showed ALL-1 gene rearrangements in 15/22 (68%) cases, p53 gene mutations in 5/22 (26%), and a homozygous deletion of p16 in a single T-ALL case. p53 and p16 alterations were all found in the group of patients with ALL-1 gene rearrangements. p53 mutations were more often associated with a myeloid phenotype (3/5).
|
9029018 |
1997 |