|
Squamous cell carcinoma of oropharynx
|
0.100 |
Biomarker
|
disease |
BEFREE |
They imply that p16 status cannot be considered a surrogate for HPV status, and those trials to de-escalate treatment in HPV+ve OSCC should take p16 status into account.
|
22146523 |
2012 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, variable clinical outcomes are observed among patients with p16 positive oropharyngeal squamous cell carcinoma, which is a surrogate marker of HPV infection.
|
29925856 |
2018 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
Biomarker
|
disease |
BEFREE |
Predictive value of computed tomography in identifying extracapsular spread of cervical lymph node metastases in p16 positive oropharyngeal squamous cell carcinoma.
|
30973213 |
2019 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
Biomarker
|
disease |
BEFREE |
The tumor was from a 48 year old non-smoking man with non-keratinizing, p16 positive tonsil OSCC, stage T2N0M0 with HPV16.
|
30909875 |
2019 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to compare survival outcomes of patients with advanced stage oropharyngeal squamous cell carcinoma (SCC) according to surgical and nonsurgical treatments, when stratified by smoking and p16 status.
|
25782372 |
2016 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
Biomarker
|
disease |
BEFREE |
We assessed a population-based cohort of patients diagnosed with oropharyngeal squamous cell carcinoma in Southeast Scotland over 13 months. p16 and human papilloma virus (HPV) expression were determined, and correlated with stage, treatment, smoking and alcohol history, and disease outcomes.
|
26152733 |
2015 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
Biomarker
|
disease |
BEFREE |
Impact of positive margins on outcomes of oropharyngeal squamous cell carcinoma according to p16 status.
|
28560813 |
2017 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
Biomarker
|
disease |
BEFREE |
HPV-DNA PCR assay yielded a high sensitivity (96%) but low specificity (11%) when compared to p16 immunohistochemistry as the reference standard.P16-positive HNSCC was predominantly observed in OPSCC (73.7%; p = 0.005); and p16-positive OPSCC exhibited improved overall survival compared to p16-negative OPSCC (p = 0.022).
|
27893418 |
2016 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
Biomarker
|
disease |
BEFREE |
The favorable prognosis of p16 (+) oropharyngeal squamous cell carcinoma suggests a need to re-examine traditional risk stratification for determining optimal adjuvant treatment.
|
27474125 |
2016 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, the prevalence of HPV and/or p16 is much lower in OOSCC compared to earlier reports including all OSCC, or tonsillar- and base of tongue cancer alone and HPV and p16 had no impact on clinical outcome in OSCC in this study.
|
23342257 |
2012 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cox regression analysis indicated that T stage and P16 status were independent factors that affected the prognosis of OPSCC patients, and the smoking index influenced the prognosis of OSCC patients.
|
28378539 |
2017 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
Biomarker
|
disease |
BEFREE |
We aimed to compare different HPV-detection methods against the test used in clinical practice, ie, p16 immunohistochemistry (IHC) and to evaluate whether another HPV-detection test additional to p16 IHC would be worthwhile in OPSCC specimens.
|
31121191 |
2019 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
Biomarker
|
disease |
BEFREE |
Partial p16 staining in oropharyngeal squamous cell carcinoma: extent and pattern correlate with human papillomavirus RNA status.
|
22596101 |
2012 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Two age, gender, stage and tumor location matched cohorts of 18 private health insured (PHIP) and 16 statutory health insured patients (SIP) suffering from an oropharyngeal squamous cell carcinoma (OSCC) and treated at a university hospital were screened for p16 overexpression and HPV infection by immunohistochemistry and PCR.
|
24065189 |
2014 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We retrospectively examined the relationship between prognosis, and p16 and p53 expression levels of oropharyngeal squamous cell carcinoma specimens in 53 patients using immunohistochemistry.
|
24470584 |
2014 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We hypothesized that p16 overexpression in OSCC defines HPV-induced tumors with favorable prognosis.
|
16401683 |
2006 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Prognostic impact of p16 and PD-L1 expression in patients with oropharyngeal squamous cell carcinoma receiving a definitive treatment.
|
31113825 |
2019 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Biopsy specimens obtained from 75 patients with OPSCC were stained for p16 and COX2 expression immunohistochemically.
|
31570459 |
2019 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The purpose of this study was to determine if oropharyngeal squamous cell carcinoma (OSCC) classified into three groups based on human papillomavirus (HPV) 16 DNA presence and p16 expression display different protein expression patterns.
|
19716018 |
2009 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition to tumor p16 expression, PD-L1 expression in TC and IC can be useful for predicting the response of OPSCC to radiotherapy.
|
30249348 |
2018 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To compare these predictors, 106 newly diagnosed OSCC for the presence of HPV-DNA and expression of p16 and EGFR were analyzed.
|
17236202 |
2007 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
HPV infection and p16 protein overexpression were detected in 53.3% and 52.4% of the OPSCCs, and each factor was associated with better overall survival (P = .0026 and P = .0026) and nonkeratinizing histology (P = .0002 and P = .0004), respectively.
|
26997438 |
2016 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Therefore, the aim of this study was to evaluate the prognostic influence of p16 expression in OPSCC and compare its relevance with the established prognostic markers cT and cN classification and the clinical stages I-IV.
|
20423915 |
2010 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Human papillomavirus infection and p16 overexpression in oropharyngeal squamous cell carcinoma: a case series from 2010 to 2014.
|
26228531 |
2015 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A novel prediction model for human papillomavirus-associated oropharyngeal squamous cell carcinoma using p16 and subcellular β-catenin expression.
|
26493274 |
2016 |