|
Squamous cell carcinoma of oropharynx
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Prognostic impact of p16 and PD-L1 expression in patients with oropharyngeal squamous cell carcinoma receiving a definitive treatment.
|
31113825 |
2019 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Biopsy specimens obtained from 75 patients with OPSCC were stained for p16 and COX2 expression immunohistochemically.
|
31570459 |
2019 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
Biomarker
|
disease |
BEFREE |
While widely used, p16 immunohistochemistry is both a sensitive and a specific surrogate marker for oncogenic HPV infection in OPSCC, but not in OSCC.
|
30238467 |
2019 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
Biomarker
|
disease |
BEFREE |
Patients with gray zone squamous cell carcinomas were compared with patients with oral cavity squamous cell carcinoma (OSCC) or oropharyngeal squamous cell carcinoma (OPSCC) and stratified by human papillomavirus (HPV) status that was determined by p16 immunostaining or HPV serology.
|
31282843 |
2019 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
Biomarker
|
disease |
BEFREE |
We retrospectively examined survival of 107 patients with locally advanced OPSCC after radiotherapy alone (n = 43) or chemoradiotherapy (n = 64) with respect to tumor p16 and HPV DNA status, using Cox's proportional hazard model.
|
30694402 |
2019 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
Biomarker
|
disease |
BEFREE |
Risk profiling based on p16 and HPV DNA more accurately predicts location of disease relapse in patients with oropharyngeal squamous cell carcinoma.
|
30657857 |
2019 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated the association between HPV and p16 status and previous results of cervical examinations, including cytological and histological tests, in females with OPSCC.
|
30626248 |
2019 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
Biomarker
|
disease |
BEFREE |
Predictive value of computed tomography in identifying extracapsular spread of cervical lymph node metastases in p16 positive oropharyngeal squamous cell carcinoma.
|
30973213 |
2019 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
Biomarker
|
disease |
BEFREE |
The tumor was from a 48 year old non-smoking man with non-keratinizing, p16 positive tonsil OSCC, stage T2N0M0 with HPV16.
|
30909875 |
2019 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of EMT markers, such as Twist and Snail/Slug, is related to p16 expression in OPSCC.
|
31704861 |
2019 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
Biomarker
|
disease |
BEFREE |
We aimed to compare different HPV-detection methods against the test used in clinical practice, ie, p16 immunohistochemistry (IHC) and to evaluate whether another HPV-detection test additional to p16 IHC would be worthwhile in OPSCC specimens.
|
31121191 |
2019 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
Biomarker
|
disease |
BEFREE |
Prognostic impact of p16 can be emphasized in a subgroup of OSCC patients undergoing surgery.
|
29936482 |
2018 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
Biomarker
|
disease |
BEFREE |
To examine combined immunoprofiles of epidermal growth factor receptor (EGFR), CD44, and p16 in oropharyngeal squamous cell carcinoma (OPSCC) and to correlate them with radiotherapy treatment outcomes and clinicopathological parameters.
|
30079604 |
2018 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
Biomarker
|
disease |
BEFREE |
We established nomograms for overall survival (OS) and progression-free survival (PFS) in patients with oropharyngeal squamous cell carcinoma (OPSCC) and known HPV-DNA and p16 status, and validated the models in cohorts from high- and low-prevalent HPV countries.
|
29795309 |
2018 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
Biomarker
|
disease |
BEFREE |
The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has been rising in Western countries and this has been attributed to human papillomavirus (HPV) infection. p16 expression is a marker for HPV infection and p16 positive OPSCC is now recognized as a separate disease entity.
|
29942347 |
2018 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
Biomarker
|
disease |
BEFREE |
To analyze the impact of tumor p16 status and other clinical factors on the therapeutic decision-making process in patients with oropharyngeal squamous cell carcinoma (OPSCC).
|
29871820 |
2018 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition to tumor p16 expression, PD-L1 expression in TC and IC can be useful for predicting the response of OPSCC to radiotherapy.
|
30249348 |
2018 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
Biomarker
|
disease |
BEFREE |
PD-L1 expression on tumor cells correlates with p16 status and advanced nodal status in OPSCC.
|
29440293 |
2018 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, variable clinical outcomes are observed among patients with p16 positive oropharyngeal squamous cell carcinoma, which is a surrogate marker of HPV infection.
|
29925856 |
2018 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, in this case, we observed that non-tumor tonsillar crypts adjacent to HPV-positive OPSCC appeared normal under a microscope; however, this tissue also showed weak p16 expression.
|
29936930 |
2018 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
Biomarker
|
disease |
BEFREE |
We evaluated three commercially available p16 antibody clones (E6H4, JC8 and G175-405) utilizing 199 cases of oropharyngeal squamous cell carcinoma from a tissue microarray, read by three pathologists with three different cutoffs for positivity: any staining, >50% and >75%.
|
28621317 |
2017 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
Biomarker
|
disease |
BEFREE |
All patients with p16 positive SCCOPx treated with definitive CRT with cisplatin between 2010 and 2014 at a single institution were retrospectively reviewed.
|
28351577 |
2017 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunohistochemistry Analysis of CD44, EGFR, and p16 in Oral Cavity and Oropharyngeal Squamous Cell Carcinoma.
|
28397583 |
2017 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
Biomarker
|
disease |
BEFREE |
Impact of positive margins on outcomes of oropharyngeal squamous cell carcinoma according to p16 status.
|
28560813 |
2017 |
|
Squamous cell carcinoma of oropharynx
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results of the present study suggested that IMP3 and p16 are more frequently expressed in OPSCC compared with other HNSCCs.
|
28789393 |
2017 |