|
Influenza A
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To develop a broad-spectrum inhibitor of influenza to combat the problem of drug resistance, we previously identified the highly conserved E339...R416 salt bridge of the nucleoprotein trimer as a target and compound <b>1</b> as an inhibitor disrupting the salt bridge with an EC<sub>50</sub> = 2.7 μM against influenza A (A/WSN/1933).
|
31769665 |
2020 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pre-exposure with influenza A virus A/WSN/1933(H1N1) resulted in viral shedding reduction from pigs challenged with either swine H1N1 or H3N2 virus.
|
30593376 |
2019 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study, a series of C-28 modified pentacyclic triterpene derivatives via conjugation with a series of polyphenols were synthesized, and their antiviral activities against influenza A/WSN/33 (H1N1) virus in MDCK (Madin-Darby canine kidney) cells were evaluated.
|
30554131 |
2019 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Some of these compounds revealed impressive anti-influenza potencies against influenza A/WSN/33 (H1N1) virus.
|
31635892 |
2019 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present work, 20 compounds were prepared by structural modifications of OA, and their antiviral activities against influenza A/WSN/33 (H1N1) virus in Madin-Darby canine kidney (MDCK) cells were evaluated.
|
31434835 |
2019 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Screening of newly developed CLK inhibitors revealed several compounds that have an effect on the level of splicing of influenza A gene segment M in different models and decrease influenza A/WSN/33 virus replication in A549 cells.
|
31176694 |
2019 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the current study, we found that whole lung and BALF TNAP expression and alkaline phosphatase enzymatic activity increased as early as 2 days postinfection (dpi) of C57BL/6 mice with 10,000 pfu/mouse of influenza A/WSN/33 (H1N1).
|
28982733 |
2018 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Infection with influenza A virus (IAV) A/WSN/1933 (H1N1) causes oxidative stress and severe lung injury.
|
29548827 |
2018 |
|
Influenza A
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here, RIG-I-knockout 293T cells were used to package the IFN-sensitive influenza A/WSN/33 (H1N1) virus expressing the mutant NS1 R38A/K41A.
|
29765910 |
2018 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
PI3Kγ knockout (KO) mice were highly susceptible to lethality following infection with influenza A/WSN/33 H1N1.
|
29867955 |
2018 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, induction of IDO appears to contribute to limiting replication of the WSN/33 strain of influenza A virus in murine NIH-3T3 cells.
|
28402179 |
2017 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study demonstrated the dissimilarity in subcellular NP transport processes between H1N1 virus WSN and other influenza A virus strains, as well as uncovered the mechanism responsible for this difference.
|
27862840 |
2017 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
An IAV pneumonia model was created by intranasal inoculation of C57BL/6 mice with influenza A/WSN/33 (H1N1) virus.
|
28912622 |
2017 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Compounds <b>20</b>, <b>28</b>, <b>36</b>, and <b>44</b> displayed weak potency to influenza A/WSN/33 (H1N1) virus (100 μM, ~20-30%), and no significant anti-influenza activity was found for the other conjugates.
|
28640212 |
2017 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conducted immunoprecipitation, followed by differential proteomic analysis, to identify proteins associating with PB2<sub>627</sub>K (human signature) and PB2<sub>627</sub>E (avian signature) of influenza A/WSN/1933(H1N1) virus, and the results indicated that Tu elongation factor, mitochondrial (TUFM), had a higher binding affinity for PB2<sub>627</sub>E than PB2<sub>627</sub>K in transfected human cells.
|
28611246 |
2017 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Antiviral testing of all compounds against influenza A virus A/WSN/33 (H1N1) in 293TGluc cells showed that nepasaikosaponin k (12), saikosaponin n (13) and saikosaponin h (14) behaved more potent inhibitory activity and selectivity than the positive control, Ribavirin.
|
28314599 |
2017 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Influenza A/WSN/33 (H1N1) virus growth and macromolecule syntheses were assessed in cultured human lung cells (A549) where the copper concentration of the growth medium was modified, or expression of host genes involved in copper homeostasis was targeted by RNA interference.
|
28115001 |
2017 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
A cell-based assay showed that three compounds (25, 28 and 31) exhibited strong inhibitory activity against influenza A/WSN/33 (H1N1) virus.
|
28411453 |
2017 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, the interaction of opioid agonists and human influenza A/WSN/33 (H1N1) virus was examined in human lung epithelial A549 cells.
|
26350582 |
2017 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Animal and in vitro models of acute lung injury were used to characterize KLF2 expression and its downstream effects responding to influenza A virus (A/WSN/33 [H1N1]), tumor necrosis factor-α, LPS, mechanical stretch/ventilation, or microvascular flow.
|
27855271 |
2017 |
|
Influenza A
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The permissive role of the R222Q was further confirmed using A/WSN/33 7:1 reassortants containing the NA gene of the oseltamivir-susceptible or oseltamivir-resistant influenza A/Mississippi/03/2001 strains.
|
25512229 |
2015 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
The C terminus of NS1 protein of influenza A/WSN/1933(H1N1) virus modulates antiviral responses in infected human macrophages and mice.
|
25934792 |
2015 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Previously, we demonstrated that influenza A/WSN/33 (H1N1) virus resulted in increased levels of the nucleotide ATP and the nucleoside adenosine in bronchoalveolar lavage fluid (BALF) of wild-type (WT) C57BL/6 mice.
|
26432867 |
2015 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
We observed that spliced ERVWE1 transcripts and those encoding the transcription factor glial cells missing 1 (GCM1), acting as an enhancer element upstream of ERVWE1, are prominently upregulated in response to influenza A/WSN/33 virus infection in nonplacental cells.
|
24478419 |
2014 |
|
Influenza A
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
C57BL/6-congenic mice heterozygous for the F508del CFTR mutation (HET) and wild-type (WT) controls were infected intranasally with 10 000 focus-forming units of influenza A/WSN/33 (H1N1) per mouse.
|
23749967 |
2013 |