Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
We aimed to synthesize epigenomic findings in HTN namely (a) angiotensin-converting enzyme 2 (ACE II) gene, (b) Toll-like receptor 2 (TLR2) gene, (c) interferon γ (IFN-γ) gene, and (d) Capping Actin Protein, Gelosin-Like (<i>CAPG</i>) <i>gene</i>, adducin 1(ADD1) gene, (e) Tissue inhibitor of metalloproteinase 3 (<i>TIMP3</i>), (f) mesoderm specific transcript (MEST) loci, (g) sodium channel epithelial 1 alpha subunit 2 (SCNN1B), (h) glucokinase (CKG) gene (i) angiotensin II receptor, type1 (AGTR1), and DNA methylation (mDNA).
|
31805646 |
2019 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Our findings indicate that the α-adducin rs4961 polymorphism may serve as a genetic biomarker of HTN in Asians.
|
30552709 |
2019 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
This study examined the SNPs AGT rs699 (Met235Thr), ADD1 rs4961 (rs4961" genes_norm="118">Gly460Trp), NPPA rs5063 (Val32Met), GPX1 rs1050450 (Pro198Leu), and AGTR1 rs5186 (A1166C) in relation to hypertension and salt sensitivity.
|
27480094 |
2017 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The results showed that Chinese with ADD1 rs4963 polymorphism showed an increased hypertension risk (OR = 1.28; 95%CI, 1.09-1.51; P = 0.003).
|
28040068 |
2016 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
The specific function of DNA methylation in regulating the expression of AH-related genes at promoter site was described for hydroxysteroid (11-beta) dehydrogenase 2 (HSD11B2), somatic angiotensin converting enzyme (sACE), Na+/K+/2Cl- cotransporter 1 (NKCC1), angiotensinogen (AGT), α-adducin (ADD1), and for other crucial genes in endocrine hypertension.
|
25035152 |
2015 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Association of alpha-ADD1 Gene and Hypertension Risk: A Meta-Analysis.
|
26042478 |
2015 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The ADD1 G460W-dominant model for the G allele was significantly associated with hypertension of IgAN patients (P = 0.001, Pc = 0.031 and OR = 1.37).
|
24271554 |
2014 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Hypertension is closely linked to ischaemic stroke (IS) and atherosclerosis, but there are no studies correlating the candidate hypertensive gene, namely angiotensin converting enzyme (ACE) and adducin 1 (ADD1) with magnetic resonance angiographic (MRA) abnormality, therefore this study was undertaken.
|
23540412 |
2013 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Thus, we carried out a case-control study and an interaction analysis to test whether ADD1 is a common candidate gene for hypertension in the Chinese population.
|
23509723 |
2013 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Computational study of ADD1 gene polymorphism associated with hypertension.
|
22810272 |
2013 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Our overall results suggest null association of α-adducin G460T and GNB3 C825T polymorphisms with hypertension in Chinese but indicate local marginal significance of C825T, as a putative salt-sensitive switch, in southern Chinese.
|
21364877 |
2011 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Further studies investigating gene-gene, gene-environment and mutual interactions are needed to better understand the role of ADD1 in hypertension.
|
21228790 |
2011 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Our case-control study and the following meta-analysis failed to provide evidence for the genetic association of alpha-adducin gene G460W polymorphism with hypertension.
|
19960031 |
2010 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Our meta-analysis failed to provide evidence for the genetic association of α-adducin gene Gly460Trp polymorphism with hypertension.
|
20927398 |
2010 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
More studies based on a larger population are required to evaluate further the role of alpha-adducin Gly460Trp polymorphism in salt-sensitive hypertension.
|
20145305 |
2010 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and the Adducin-1 (ADD1) G460W nonsense single nucleotide polymorphism (SNP) have previously been associated to hypertension, whereas their association with preeclampsia (PE) and gestational hypertension (GH) is still controversial.
|
19443911 |
2009 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
[Association of the polymorphisms of sodium transport related genes with essential hypertension].
|
19199261 |
2009 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The Gly460Trp variant of the alpha-adducin gene has been associated with the salt-sensitive and diuretic responsive form of hypertension.
|
19145769 |
2009 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
We studied the risk of stroke, coronary heart disease (CHD), and myocardial infarction (MI) associated with the alpha-adducin variant and examined the extent to which this risk is modified by the presence of hypertension.
|
18458162 |
2008 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Genetic variation in alpha-adducin cytoskeletal protein is implicated in the polymerization and bundling of actin and alteration of the Na/K pump, resulting in abnormal renal sodium transport and hypertension in Milan hypertensive rats and humans.
|
18524856 |
2008 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
ADD1 Gly460Trp polymorphism is associated with salt-sensitive hypertension and increased Na-K pump activity in transfected cells.
|
18667944 |
2008 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
LHGDN |
The alpha-adducin gene TT and ACE II genotypes might be genetic susceptibility factors to hypertension accompanying renal injury.
|
18393230 |
2008 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The alpha-adducin (ADD1) Gly460Trp polymorphism has been associated with hypertension and response to diuretic therapy, but controversy exists.
|
18657677 |
2008 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The ADD1 Gly460Trp polymorphism is significantly associated with an increased risk of coronary artery disease as well as blood pressure, indicating that ADD1 plays a role in the pathogenesis of coronary artery disease as well as hypertension.
|
17984662 |
2007 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
LHGDN |
The ADD1 Gly460Trp polymorphism is significantly associated with an increased risk of coronary artery disease as well as blood pressure, indicating that ADD1 plays a role in the pathogenesis of coronary artery disease as well as hypertension.
|
17984662 |
2007 |