Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This association remained statistically significant after the multivariate analysis (odds ratio 2.548, P = .02).The ADD1 Gly460Trp gene polymorphism is significantly and independently associated with EH risk in our population.
|
29049185 |
2017 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This work showed that the interaction between the ADD1 rs4961 variant, obesity, and the presence of diabetes increased the susceptibility to EH four-fold.
|
28872890 |
2017 |
Essential Hypertension
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
These findings highlight that ADD1 methylation may have a contributing role in the pathogenesis of EH with varying implications for both genders.
|
28686109 |
2017 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Essential hypertension patients were genotyped for 11 polymorphisms of essential hypertension susceptibility genes including ADD1 (rs4961), GNB3 (rs5443, rs16932941), NOS3 (rs1799983, rs2070744), ACE (rs5186), AGTR1 (rs5186), AGT (rs699, rs4762), MR (rs5534), and TGFB1 (rs1800471).
|
26335431 |
2015 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Logistic regression was used to assess the associations of ADD1 tagSNPs, environmental factors and EH.
|
25567773 |
2015 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The findings showed the association of the T allele in ADD1 gene with EH susceptibility in Asians.
|
26042478 |
2015 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A significant association was found between ADD1 gene G614T polymorphism and EH in Chinese patients.
|
24718403 |
2014 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The present study indicated that rs4963 within ADD1 gene was associated with essential hypertension in Chinese population, which might be related to altered exonic splicing and disrupted gene regulation.
|
23509723 |
2013 |
Essential Hypertension
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Lower ADD1 gene promoter DNA methylation increases the risk of essential hypertension.
|
23691048 |
2013 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
There was a significant association between the α-adducin G460W gene polymorphism and EH in the pooled Chinese population under both an allelic genetic model (OR: 1.12, 95% CI: 1.04-1.20, P = 0.002) and a recessive genetic model (OR: 1.40, 95% CI: 1.16-1.70, P = 0.0005).
|
22272309 |
2012 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Overall, our findings supported the hypothesis that the ADD1 Gly460Trp polymorphism is associated with EH in the Chinese population.
|
21228790 |
2011 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To determine whether four potential genetic factors (polymorphisms in genes for alpha-adducin, beta-adducin, the G-protein beta-3 subunit and nitric oxide synthase) are important for the development of essential hypertension (EH) in Slovenian children and young adults with EH.
|
16497648 |
2006 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In both humans and rats, polymorphisms of the alpha adducin (ADD1) gene are involved in renal sodium handling, essential hypertension and some of its organ complications.
|
15716695 |
2005 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Sodium-lithium countertransport and the Gly460-->Trp alpha-adducin polymorphism in essential hypertension.
|
15554870 |
2005 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants of alpha adducin (ADD1) taken alone or in interaction with those of beta (ADD2) and gamma (ADD3) subunits have been associated with primary hypertension in humans and in Milan hypertensive (MHS) rats.
|
15474463 |
2004 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study investigated the relationship between the Gly460Trp polymorphism of ADD-1 and essential hypertension in a Korean population.
|
15608390 |
2004 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Alpha-adducin Gly460Trp polymorphism and renal hemodynamics in essential hypertension.
|
15326084 |
2004 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This review is thought to highlight current strategies towards a better understanding of the genetic background of essential hypertension with particular respect to genetic variants of the renin-angiotensin system, of signaling pathways such as heterotrimeric G-proteins and alpha-adducin.
|
15467511 |
2004 |
Essential Hypertension
|
0.400 |
Biomarker
|
disease |
BEFREE |
Five candidate genes including the lipoprotein lipase, leptin, leptin receptor, alpha-adducin and beta3 adrenergic receptor were selected to examine their possible contribution to essential hypertension (EH) in a Chinese population.
|
12571619 |
2003 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The present findings show a positive association between the alpha-adducin G460W polymorphism and essential hypertension in a northern Chinese population.
|
14508192 |
2003 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The Gly460Trp polymorphism of the alpha-adducin gene (ADD-1 ) has been examined as a candidate gene for essential hypertension with salt sensitivity in the Caucasian population.
|
12195119 |
2002 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study was designed to examine the linkage between alpha-adducin gene locus and essential hypertension and to reveal the relationship between an alpha-adducin gene polymorphism (Gly460Trp) and essential hypertension in a Chinese population.
|
11710759 |
2001 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recent studies have found the tryptophan allele of a glycine to tryptophan polymorphism at position 460 (G460W) of the alpha-adducin protein to be associated with essential hypertension in European populations.
|
10912757 |
2000 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
alpha-adducin and angiotensin I-converting enzyme polymorphisms in essential hypertension.
|
11116113 |
2000 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Role of the Gly460Trp polymorphism of the alpha-adducin gene in primary hypertension in Scandinavians.
|
10673730 |
2000 |