|
Tumor Cell Invasion
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
The expression level of ClC-3 was closely-related to the histological differentiation (p = 0.029), tumour staging (<i>p </i>= 0.016), tumour size (<i>p </i>= 0.039), vascular invasion (<i>p </i>= 0.045), interstitial infiltration depth (<i>p </i>= 0.012), lymphatic metastasis (<i>p </i>= 0.036), and HPV infection (<i>p </i>= 0.022).
|
30636929 |
2019 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
The purpose of this study was to evaluate whether ClC-3 influences the migration and invasion of cervical squamous cell carcinoma cells and its possible mechanisms.
|
30905432 |
2019 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, higher expression of CLC-3 was correlated with deeper tumor invasion (P = 0.006) and increased lymph node metastasis (P = 0.016), and knockdown of CLC-3 inhibited cell proliferation and migration in vitro.
|
30217218 |
2018 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
An ITALIC! in vitro investigation of the effect of ClC-3 on the migration and invasion of ectopic ESCs from patients with endometriosis.
|
26965430 |
2016 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Therefore, cytoplasmic ClC-3 plays an active and key role in tumor metastasis and may be a valuable prognostic biomarker and a therapeutic target to prevent tumor spread.
|
25537517 |
2015 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
ClC-3 may be an important promoter for aggressive metastasis of malignant tumors.
|
30636929 |
2019 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Chloride channel 3 (CIC-3) has been suggested to be implicated in the carcinogenesis though; it still remains ill understood in hepatocarcinoma, especially in terms of clinicopathological meaning of its expression.
|
30678806 |
2019 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
ClC-3 is a type of chloride channel that has multiple functions in tumorigenesis and tumor growth, and can be blocked by DIDS (4,4'-diisothiocyanostilbene-2,2'-disulfonic acid).
|
29749557 |
2018 |
|
Vascular inflammations
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, TNFα-induced vascular inflammation and neutrophil infiltration into the lung and liver were obviously attenuated in ClC-3 knockout mice (P<0.01; n=7).
|
23006728 |
2012 |
|
Vascular inflammations
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Our previous study found that ClC-3 chloride channel functioned differently in the vascular and intestinal inflammation, the loss of ClC-3 reduced vascular inflammation but exacerbated intestinal inflammation.
|
29972266 |
2018 |
|
Chorea
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Considering that chorea in this patient might be due to the disruption of a gene at either of the 4p15.32 or 4q33 breakpoints, CLCN3 was considered as a candidate gene.
|
9521585 |
1998 |
|
Dysmenorrhea
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
ClC-3 expression level was well-correlated to the clinical characteristics and symptoms of endometriosis patients, including infertility, dysmenorrhea, chronic pelvic pain, dyspareunia and diameter of endometriosis lesion.
|
26965430 |
2016 |
|
Hyperalgesia
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Cltx causes hyperalgesia and decreased expression of ClC-3 in OVX rats.
|
31787875 |
2019 |
|
Neuralgia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Intrathecal Cltx to OVX and OVX + SNI rats was administered for 4 consecutive days (days 7-10 after SNI) to further determine the contribution of ClC-3 to neuropathic pain.
|
31787875 |
2019 |
|
Seizures
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Blocking CLC-3 Cl<sup>-</sup> channels by gluconate inhibits seizure activity both in neonatal brain slices and in neonatal animals with in vivo EEG recordings.
|
31088565 |
2019 |
|
Endotoxemia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Therefore, the regulation of intestinal tissue integrity by ClC-3 is crucial for maintaining LPS-induced survival in mice with endotoxemia.
|
29972266 |
2018 |
|
Developmental delay (disorder)
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Together with developmental retardation and higher mortality, the Clcn3-/- mice showed neurological manifestations such as blindness, motor coordination deficit, and spontaneous hyperlocomotion.
|
12059962 |
2002 |
|
Blindness
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Together with developmental retardation and higher mortality, the Clcn3-/- mice showed neurological manifestations such as blindness, motor coordination deficit, and spontaneous hyperlocomotion.
|
12059962 |
2002 |
|
Nasopharyngeal carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The ClC-3 chloride channel protein is a downstream target of cyclin D1 in nasopharyngeal carcinoma cells.
|
23270726 |
2013 |
|
Nasopharyngeal carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
ClC-3 protein may be considered as a potential tumor marker and therapeutic target for human nasopharyngeal carcinoma.
|
22108225 |
2012 |
|
Nasopharyngeal carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
ClC-3 may regulate CNE-2Z cell migration by modulating cell volume.
|
18359479 |
2008 |
|
Nasopharyngeal carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Nevertheless, ClC-3 knockdown had little effect on ROS levels, indicating that ROS acted upstream of ClC-3 and that both ROS and ClC-3 participated in EBSS-induced autophagy regulation in CNE-2Z.
|
30992317 |
2019 |
|
Nasopharyngeal carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The AQP-3 water channel and the ClC-3 chloride channel coordinate the hypotonicity-induced swelling volume in nasopharyngeal carcinoma cells.
|
25450461 |
2014 |
|
Nasopharyngeal carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
ClC-3 is a candidate of the channel proteins that mediate or regulate the acid-activated chloride current in nasopharyngeal carcinoma cells.
|
22496242 |
2012 |
|
Nasopharyngeal carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
ClC-3 is a main component of background chloride channels activated under isotonic conditions by autocrine ATP in nasopharyngeal carcinoma cells.
|
21792908 |
2011 |