ANTXR2, ANTXR cell adhesion molecule 2, 118429

N. diseases: 143; N. variants: 27
Disease: Anthrax disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003175
Disease: Anthrax disease
Anthrax disease 		0.300 GeneticVariation disease BEFREE The disease is caused by either a homozygous or compound heterozygous mutation of the anthrax toxin receptor 2 (ANTXR2) gene. 30152846 2018
CUI: C0003175
Disease: Anthrax disease
Anthrax disease 		0.300 Biomarker disease BEFREE Capillary morphogenesis protein 2 (CMG2) was originally identified through its participation in capillary morphogenesis, and subsequently identified as the second receptor for anthrax toxin (ANTXR2). 29473166 2018
CUI: C0003175
Disease: Anthrax disease
Anthrax disease 		0.300 Biomarker disease BEFREE The protein-protein interaction between the human CMG2 receptor and the Bacillus anthracis protective antigen (PA) is essential for the transport of anthrax lethal and edema toxins into human cells. 28596569 2017
CUI: C0003175
Disease: Anthrax disease
Anthrax disease 		0.300 Biomarker disease BEFREE Stability of domain 4 of the anthrax toxin protective antigen and the effect of the VWA domain of CMG2 on stability. 27874231 2017
CUI: C0003175
Disease: Anthrax disease
Anthrax disease 		0.300 AlteredExpression disease BEFREE These findings further our understanding of human variability in ANTXR2 expression and anthrax toxin susceptibility. 26703731 2015
CUI: C0003175
Disease: Anthrax disease
Anthrax disease 		0.300 Biomarker disease BEFREE A recent genome-wide association study or GWAS identified that anthrax roxin receptor 2 (ANTXR2) was one of the risk loci for ankylosing spondylitis (AS). 25736362 2015
CUI: C0003175
Disease: Anthrax disease
Anthrax disease 		0.300 Biomarker disease BEFREE Silencing CMG2 using targeted siRNAs provided almost complete protection against anthrax lethal toxin-induced cytotoxicity and death in murine and human macrophages. 24742682 2014
CUI: C0003175
Disease: Anthrax disease
Anthrax disease 		0.300 Biomarker disease BEFREE The anthrax toxin receptor 2 (ANTXR2) is a type I membrane protein acting as the second receptor for the anthrax toxin. 24924630 2014
CUI: C0003175
Disease: Anthrax disease
Anthrax disease 		0.300 Biomarker disease BEFREE Capillary morphogenesis gene 2 (CMG2) is a receptor of anthrax toxin and plays an important role in angiogenesis. 24993339 2014
CUI: C0003175
Disease: Anthrax disease
Anthrax disease 		0.300 Biomarker disease BEFREE To explore whether proteins other than TEM8 and CMG2 function as anthrax toxin receptors in vivo, we challenged mice lacking TEM8 and/or CMG2. 23271637 2012
CUI: C0003175
Disease: Anthrax disease
Anthrax disease 		0.300 Biomarker disease BEFREE We will here review what is known about the structure of CMG2 and its ability to mediate anthrax toxin entry into cell. 22215446 2012
CUI: C0003175
Disease: Anthrax disease
Anthrax disease 		0.300 Biomarker disease BEFREE Treatment with CMG2-Fc did not interfere with the development of the animals' own immunity to anthrax, as treated animals that survived an initial challenge also survived a rechallenge 30 days later. 20956592 2011
CUI: C0003175
Disease: Anthrax disease
Anthrax disease 		0.300 Biomarker disease BEFREE The anthrax toxin receptors tumor endothelial marker-8 (TEM-8) and capillary morphogenesis gene-2 (CMG-2) are responsible for allowing entry of anthrax toxin into host cells. 21196249 2011
CUI: C0003175
Disease: Anthrax disease
Anthrax disease 		0.300 Biomarker disease BEFREE The Capillary Morphogenesis Gene 2 (CMG2) gene encodes an Anthrax toxin receptor (ANTXR2), but the normal physiological function is not known. 19901963 2010
CUI: C0003175
Disease: Anthrax disease
Anthrax disease 		0.300 Biomarker disease BEFREE In this study, we describe the identification and characterization of two murine monoclonal immunoglobulin G1 antibodies (MAbs), 1-F1 and 2-B12, which recognize distinct linear neutralizing epitopes on domain 4 of PA. 1-F1 recognized a 12-mer peptide corresponding to residues 692 to 703; this epitope maps to a region of domain 4 known to interact with the anthrax toxin receptor CMG-2 and within a conformation-dependent epitope recognized by the well-characterized neutralizing MAb 14B7. 19703971 2009
CUI: C0003175
Disease: Anthrax disease
Anthrax disease 		0.300 Biomarker disease BEFREE Moreover, we observed efficient PA-mediated uptake into anthrax toxin receptor (ANTXR)-deficient Chinese hamster ovary cells (PR230) that had been stably engineered to express either human ANTXR1 or human ANTXR2 in the presence or absence of siRNA specific for LRP5 or LRP6. 17335347 2007
CUI: C0003175
Disease: Anthrax disease
Anthrax disease 		0.300 Biomarker disease BEFREE Bacillus anthracis protective antigen (PA), the B subunit of the binary anthrax toxin, binds to the cellular receptors capillary morphogenesis gene 2 protein and tumor endothelial marker 8 with high affinity. 17942931 2007
CUI: C0003175
Disease: Anthrax disease
Anthrax disease 		0.300 Biomarker disease RGD Moreover, a D683K mutant form of PA that bound specifically to human and rat ANTXR2 mediated killing of rats by anthrax lethal toxin, providing strong evidence for the physiological importance of ANTXR2 in anthrax disease pathogenesis. 17054395 2006