Ankylosing spondylitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A meta-analysis was performed to evaluate the associations of polymorphisms in the ANTXR2 gene with AS.
|
30255098 |
2018 |
Ankylosing spondylitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The association between ANTXR2 rs4333130 and AS was independent of HLA-B27 status.
|
26590821 |
2016 |
Ankylosing spondylitis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
ANTXR2 messenger RNA (mRNA) expression was significantly higher in the AS group than in the control group (P = 0.039).
|
26728147 |
2016 |
Ankylosing spondylitis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
Ankylosing spondylitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
This study aimed to investigate the possible mechanisms of ANTXR2 involved in AS pathogenesis.
|
25736362 |
2015 |
Ankylosing spondylitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We also used data for AS patients from previous genome-wide association studies to investigate the AS risk locus ANTXR2 for its putative effect in AAU.
|
25200001 |
2015 |
Ankylosing spondylitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Further studies are required to clarify the role played by these ANTXR2 variants in AS.
|
25169729 |
2014 |
Ankylosing spondylitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
No association was observed between AS and ANTXR2 or IL-1R2 in present study, indicating that the polymorphisms in the ANTXR2 and IL-1R2 gene may not be regarded as major contributors to AS susceptibility in Chinese Han population.
|
20652271 |
2012 |
Ankylosing spondylitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Thus, the six SNPs of ANTXR2 are not associated with AS in our Chinese Shandong Han population.
|
22118297 |
2012 |
Ankylosing spondylitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Here we report the identification of three variants in the RUNX3, LTBR-TNFRSF1A and IL12B regions convincingly associated with ankylosing spondylitis (P < 5 × 10(-8) in the combined discovery and replication datasets) and a further four loci at PTGER4, TBKBP1, ANTXR2 and CARD9 that show strong association across all our datasets (P < 5 × 10(-6) overall, with support in each of the three datasets studied).
|
21743469 |
2011 |
Ankylosing spondylitis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.
|
21743469 |
2011 |
Ankylosing spondylitis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.
|
21743469 |
2011 |
Ankylosing spondylitis
|
0.500 |
Biomarker
|
disease |
CTD_human |
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.
|
21743469 |
2011 |
Ankylosing spondylitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Investigators from the Australo-Anglo-American Spondyloarthritis Consortium have reported additional genes associated with ankylosing spondylitis (AS) susceptibility including IL1R2, ANTXR2, and gene deserts at 2p15 and 21q22.
|
21041274 |
2011 |
Ankylosing spondylitis
|
0.500 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci.
|
20062062 |
2010 |
Ankylosing spondylitis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci.
|
20062062 |
2010 |
Ankylosing spondylitis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci.
|
20062062 |
2010 |