|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
IGF-II-Conjugated Nanocarrier for Brain-Targeted Delivery of p11 Gene for Depression.
|
30617637 |
2019 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
The molecular associations of depression behavior with anxiety and memory deficit suggested a potential approach to improve therapeutic intervention through P11 in these disorders.
|
31337969 |
2019 |
|
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
The molecular associations of depression behavior with anxiety and memory deficit suggested a potential approach to improve therapeutic intervention through P11 in these disorders.
|
31337969 |
2019 |
|
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
IGF-II-Conjugated Nanocarrier for Brain-Targeted Delivery of p11 Gene for Depression.
|
30617637 |
2019 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The molecular associations of depression behavior with anxiety and memory deficit suggested a potential approach to improve therapeutic intervention through P11 in these disorders.
|
31337969 |
2019 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
IGF-II-Conjugated Nanocarrier for Brain-Targeted Delivery of p11 Gene for Depression.
|
30617637 |
2019 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Reviewing the literature concerning BNDF, p11 and Homer1a we here describe a molecular network in which these molecules interact with each other finally leading to facilitation of AMPA receptor signaling and plasticity, corroborating the current idea of AMPA receptors being a promising drug target in depression.
|
29550211 |
2018 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results have identified p11 in LHb as a key molecular determinant regulating negative emotions, which may help to understand the molecular and cellular basis of depression.
|
28507317 |
2018 |
|
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results have identified p11 in LHb as a key molecular determinant regulating negative emotions, which may help to understand the molecular and cellular basis of depression.
|
28507317 |
2018 |
|
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Reviewing the literature concerning BNDF, p11 and Homer1a we here describe a molecular network in which these molecules interact with each other finally leading to facilitation of AMPA receptor signaling and plasticity, corroborating the current idea of AMPA receptors being a promising drug target in depression.
|
29550211 |
2018 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Reviewing the literature concerning BNDF, p11 and Homer1a we here describe a molecular network in which these molecules interact with each other finally leading to facilitation of AMPA receptor signaling and plasticity, corroborating the current idea of AMPA receptors being a promising drug target in depression.
|
29550211 |
2018 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These results have identified p11 in LHb as a key molecular determinant regulating negative emotions, which may help to understand the molecular and cellular basis of depression.
|
28507317 |
2018 |
|
Mental Depression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Monocyte, natural killer (NK) cell, and cytotoxic T-cell p11 levels were positively associated with the severity of PD, and NK cell p11 levels were positively associated with depression scores.
|
28137881 |
2017 |
|
Mental Depression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results have identified p11 as a key molecule in a specific cell type that regulates stress-induced depression, which provides a framework for the development of new strategies to treat stress-associated mental illnesses.
|
27457815 |
2017 |
|
Depressive disorder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results have identified p11 as a key molecule in a specific cell type that regulates stress-induced depression, which provides a framework for the development of new strategies to treat stress-associated mental illnesses.
|
27457815 |
2017 |
|
Depressive disorder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Monocyte, natural killer (NK) cell, and cytotoxic T-cell p11 levels were positively associated with the severity of PD, and NK cell p11 levels were positively associated with depression scores.
|
28137881 |
2017 |
|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Monocyte, natural killer (NK) cell, and cytotoxic T-cell p11 levels were positively associated with the severity of PD, and NK cell p11 levels were positively associated with depression scores.
|
28137881 |
2017 |
|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Our results have identified p11 as a key molecule in a specific cell type that regulates stress-induced depression, which provides a framework for the development of new strategies to treat stress-associated mental illnesses.
|
27457815 |
2017 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings suggested that p11 might be a potential regulator on 5-HTR1b and 5-HTR4 as well as a predictor of or a therapeutic target for IFN-α-induced depression.
|
26821757 |
2016 |
|
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings suggested that p11 might be a potential regulator on 5-HTR1b and 5-HTR4 as well as a predictor of or a therapeutic target for IFN-α-induced depression.
|
26821757 |
2016 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our findings suggested that p11 might be a potential regulator on 5-HTR1b and 5-HTR4 as well as a predictor of or a therapeutic target for IFN-α-induced depression.
|
26821757 |
2016 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we tested the leukocyte mRNA expression levels of genes belonging to glucocorticoid receptor (GR) function (FKBP-4, FKBP-5, and GR), inflammation (interleukin (IL)-1α, IL-1β, IL-4, IL-6, IL-7, IL-8, IL-10, macrophage inhibiting factor (MIF), and tumor necrosis factor (TNF)-α), and neuroplasticity (brain-derived neurotrophic factor (BDNF), p11 and VGF), in healthy controls (n=34) and depressed patients (n=74), before and after 8 weeks of treatment with escitalopram or nortriptyline, as part of the Genome-based Therapeutic Drugs for Depression study.
|
22990943 |
2013 |
|
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we tested the leukocyte mRNA expression levels of genes belonging to glucocorticoid receptor (GR) function (FKBP-4, FKBP-5, and GR), inflammation (interleukin (IL)-1α, IL-1β, IL-4, IL-6, IL-7, IL-8, IL-10, macrophage inhibiting factor (MIF), and tumor necrosis factor (TNF)-α), and neuroplasticity (brain-derived neurotrophic factor (BDNF), p11 and VGF), in healthy controls (n=34) and depressed patients (n=74), before and after 8 weeks of treatment with escitalopram or nortriptyline, as part of the Genome-based Therapeutic Drugs for Depression study.
|
22990943 |
2013 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In this study, we tested the leukocyte mRNA expression levels of genes belonging to glucocorticoid receptor (GR) function (FKBP-4, FKBP-5, and GR), inflammation (interleukin (IL)-1α, IL-1β, IL-4, IL-6, IL-7, IL-8, IL-10, macrophage inhibiting factor (MIF), and tumor necrosis factor (TNF)-α), and neuroplasticity (brain-derived neurotrophic factor (BDNF), p11 and VGF), in healthy controls (n=34) and depressed patients (n=74), before and after 8 weeks of treatment with escitalopram or nortriptyline, as part of the Genome-based Therapeutic Drugs for Depression study.
|
22990943 |
2013 |
|
Mental Depression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Recently, it was found that p11 is associated with traumatic stress and depression, and glucocorticoids regulate expression of the p11 gene.
|
21367534 |
2011 |