SERPINA3, serpin family A member 3, 12

N. diseases: 229; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011311
Disease: Dengue Fever
Dengue Fever
0.010 Biomarker disease BEFREE The expression levels of leucine-rich alpha-2-glycoprotein (LRG1) and alpha-1-antichymotrypsin (ACT) were different significantly between leptospirosis and healthy group but not to the dengue control group. 31029530 2020
CUI: C0019202
Disease: Hepatolenticular Degeneration
Hepatolenticular Degeneration
0.010 AlteredExpression disease BEFREE The plasma proteome changes observed in the Atp7b-/- mouse were not confirmed in these samples, except for alpha-1 antichymotrypsin, levels of which were decreased in WD patients compared to healthy individuals. 31815268 2020
CUI: C0023364
Disease: Leptospirosis
Leptospirosis
0.010 Biomarker disease BEFREE The expression levels of leucine-rich alpha-2-glycoprotein (LRG1) and alpha-1-antichymotrypsin (ACT) were different significantly between leptospirosis and healthy group but not to the dengue control group. 31029530 2020
CUI: C0741923
Disease: cardiac event
cardiac event
0.010 AlteredExpression phenotype BEFREE Circulating Serpina3 levels predict the major adverse cardiac events in patients with myocardial infarction. 31439424 2020
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.010 Biomarker disease BEFREE There was no correlation between SERPINA3 protein in endometrial cancer cells and the age range at which women experienced menopause (<i>P</i> > 0.05). 31423431 2019
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.010 Biomarker disease BEFREE In our previously study, we identified glycoprotein alpha-1-antichymotrypsin (AACT) as an early biomarker of NSCLC. 30607521 2019
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma
0.010 Biomarker disease BEFREE A patient was found incidentally on dual-tracer (C-acetate [ACT] and F-FDG [FDG]) PET/CT for having crossed fused renal ectopia and 2 types of malignant tumors, colonic carcinoma and renal cell carcinoma (RCC), each having its own characteristic tracer avidity. 30608912 2019
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.010 GeneticVariation group BEFREE Withholding the Introduction of Anti-Epidermal Growth Factor Receptor: Impact on Outcomes in <i>RAS</i> Wild-Type Metastatic Colorectal Tumors: A Multicenter AGEO Study (the WAIT or ACT Study). 31578276 2019
CUI: C0015672
Disease: Fatigue
Fatigue
0.010 Biomarker phenotype BEFREE Correlation of fatigue with other disease related and psychosocial factors in patients with rheumatoid arthritis treated with tocilizumab: ACT-AXIS study. 31261500 2019
CUI: C0017668
Disease: Focal glomerulosclerosis
Focal glomerulosclerosis
0.010 Biomarker disease BEFREE An early and progressive elevation of urinary SerpinA3 (uSerpinA3) was observed during the AKI to CKD transition together with SerpinA3 relocation from the cytoplasm to the apical tubular membrane in the rat kidney. uSerpinA3/alpha-1-antichymotrypsin was significantly increased in patients with CKD secondary to focal and segmental glomerulosclerosis (FSGS), ANCA associated vasculitis (AAV) and proliferative class III and IV lupus nephritis (LN). uSerpinA3 levels were independently and positively associated with renal fibrosis. 31316093 2019
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.010 Biomarker disease BEFREE An early and progressive elevation of urinary SerpinA3 (uSerpinA3) was observed during the AKI to CKD transition together with SerpinA3 relocation from the cytoplasm to the apical tubular membrane in the rat kidney. uSerpinA3/alpha-1-antichymotrypsin was significantly increased in patients with CKD secondary to focal and segmental glomerulosclerosis (FSGS), ANCA associated vasculitis (AAV) and proliferative class III and IV lupus nephritis (LN). uSerpinA3 levels were independently and positively associated with renal fibrosis. 31316093 2019
CUI: C0024537
Disease: Malaria, Vivax
Malaria, Vivax
0.010 Biomarker disease BEFREE Plasmodium vivax malaria elimination can only be achieved by the deployment of 8-aminoquinolines (primaquine and tafenoquine) in combination with ACT to kill both blood and liver-stage parasites. 30674319 2019
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases
0.010 Biomarker group BEFREE The unique presence of serpin A3-7, coiled-coil domain containing 88A and inhibin/activin β A chain in HR-EXO, indicates potential biomarkers for cows at-risk for metabolic diseases. 31554846 2019
CUI: C0027430
Disease: Nasal Polyps
Nasal Polyps
0.010 Biomarker disease BEFREE ACT-774312 is an antagonist of the chemoattractant receptor-homologous molecule expressed on T helper (Th) 2 cells (CRTH2), in development for the treatment of nasal polyposis or other allergic and type-2 inflammatory diseases. 30589994 2019
CUI: C0037856
Disease: Spermatic Cord Torsion
Spermatic Cord Torsion
0.010 Biomarker disease BEFREE We sought to optimize management of acute testicular torsion at a single institution by decreasing time from presentation to definitive management through the creation and implementation of a clinical care pathway (accelerated care of torsion or ACT) for acute testicular torsion in a 2-year period. 31444122 2019
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes
0.010 Biomarker phenotype BEFREE I-ACT primarily aims to examine objectively measured PA levels and patterns in first and second trimesters of pregnancy and the association with GDM and/or GH in Singapore, a multiethnic Asian population. 30948592 2019
CUI: C0277528
Disease: Traveler's diarrhea
Traveler's diarrhea
0.010 Biomarker disease BEFREE The cephamycinase ACT-20 is described in the present study for the first time in EAEC and ETEC strains causing TD in patients who had traveled to Central America. 30478165 2019
Conventional (Clear Cell) Renal Cell Carcinoma
0.010 Biomarker disease BEFREE A patient was found incidentally on dual-tracer (C-acetate [ACT] and F-FDG [FDG]) PET/CT for having crossed fused renal ectopia and 2 types of malignant tumors, colonic carcinoma and renal cell carcinoma (RCC), each having its own characteristic tracer avidity. 30608912 2019
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.010 Biomarker disease BEFREE There was no correlation between SERPINA3 protein in endometrial cancer cells and the age range at which women experienced menopause (<i>P</i> > 0.05). 31423431 2019
CUI: C0852036
Disease: Pregnancy associated hypertension
Pregnancy associated hypertension
0.010 GeneticVariation phenotype BEFREE I-ACT primarily aims to examine objectively measured PA levels and patterns in first and second trimesters of pregnancy and the association with GDM and/or GH in Singapore, a multiethnic Asian population. 30948592 2019
CUI: C1561643
Disease: Chronic Kidney Diseases
Chronic Kidney Diseases
0.010 Biomarker group BEFREE An early and progressive elevation of urinary SerpinA3 (uSerpinA3) was observed during the AKI to CKD transition together with SerpinA3 relocation from the cytoplasm to the apical tubular membrane in the rat kidney. uSerpinA3/alpha-1-antichymotrypsin was significantly increased in patients with CKD secondary to focal and segmental glomerulosclerosis (FSGS), ANCA associated vasculitis (AAV) and proliferative class III and IV lupus nephritis (LN). uSerpinA3 levels were independently and positively associated with renal fibrosis. 31316093 2019
CUI: C1561826
Disease: Overweight and obesity
Overweight and obesity
0.010 GeneticVariation disease BEFREE Using a series of height and weight assessments from the Australian Capital Territory Physical Activity and Nutrition Survey (ACTPANS), trends in prevalence of overweight and obesity by socioeconomic status were examined in ACT Year 6 school children between 2006 and 2018. 31718605 2019
CUI: C2217035
Disease: Stage IIA Colon Cancer AJCC v7
Stage IIA Colon Cancer AJCC v7
0.010 Biomarker disease BEFREE <b>Conclusion:</b> ACT did not show substantial survival benefit in stage IIA colon cancer with elevated pretreatment serum CEA levels. 30815388 2019
CUI: C4525122
Disease: Stage IIA Colon Cancer AJCC v8
Stage IIA Colon Cancer AJCC v8
0.010 Biomarker disease BEFREE <b>Conclusion:</b> ACT did not show substantial survival benefit in stage IIA colon cancer with elevated pretreatment serum CEA levels. 30815388 2019
CUI: C4551689
Disease: Sleep-Disordered Breathing
Sleep-Disordered Breathing
0.010 Biomarker disease BEFREE Treatment of SDB improves asthma outcomes as measured by the C-ACT. 30489041 2019