SERPINA3, serpin family A member 3, 12

N. diseases: 229; N. variants: 8
Disease: Impaired cognition ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.050 GeneticVariation disease BEFREE A SNP in the ACT gene associated with astrocytosis and rapid cognitive decline in AD. 17368652 2008
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.050 GeneticVariation disease BEFREE To assess whether serum levels of the inflammatory proteins alpha(1)-antichymotrypsin (ACT), C-reactive protein (CRP), interleukin-6 (IL-6), and albumin are associated with cognitive decline in older persons. 15851726 2005
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.050 GeneticVariation disease BEFREE After manifestation of the disease the ACT TT genotype was also associated with faster cognitive decline in patients with the APOE allele epsilon 4. 15653173 2005
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.050 GeneticVariation disease BEFREE Recent reports suggest that the T allele of a G/T polymorphism at position -51 of ACT is associated with cognitive decline in AD patients. 15530656 2004
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.050 GeneticVariation disease BEFREE Rate of cognitive decline in Alzheimer's disease is not affected by the alpha-1-antichymotrypsin A allele or the CYP2D6 B mutant. 8916107 1996