PARKINSON DISEASE 8 (disorder)
|
0.930 |
GeneticVariation
|
disease |
BEFREE |
Multiple mutations in the gene for the leucine-rich repeat kinase (LRRK2) cause autosomal dominant late-onset parkinsonism (PARK8).
|
16254973 |
2005 |
PARKINSON DISEASE 8 (disorder)
|
0.930 |
GeneticVariation
|
disease |
BEFREE |
Mutations in PARK8 (LRRK2) are associated with autosomal dominant parkinsonism and Parkinson disease (PD).
|
18809839 |
2008 |
PARKINSON DISEASE 8 (disorder)
|
0.930 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been identified in pedigrees of autosomal-dominant familial Parkinson's disease (PARK8).
|
23924436 |
2013 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Missense mutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset Parkinson's disease (PD), and common genetic variation in LRRK2 modifies susceptibility to Crohn's disease and leprosy.
|
22302802 |
2012 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Association studies have identified several signals at the LRRK2 locus for Parkinson's disease (PD), Crohn's disease (CD) and leprosy.
|
23967090 |
2013 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Additionally, in genome-wide association studies, the LRRK2 locus has been linked to risk of PD, Crohn's disease and leprosy, and LRRK2 has also been linked with cancer.
|
22988880 |
2012 |
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
LRRK2, the gene encoding the multidomain kinase Leucine-Rich Repeat Kinase 2 (LRRK2), has been linked to familial and sporadic forms of Parkinson's disease (PD), as well as cancer, leprosy and Crohn's disease, establishing it as a target for discovery therapeutics.
|
30055128 |
2018 |
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
We studied associations between nonsynonymous coding variants in the MUC19 (5) and LRRK2 (3) genes in a case-control sample comprising CD cases aged <18 years at diagnosis.
|
23619718 |
2013 |
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Leucine-rich repeat kinase 2 (<i>LRRK2</i>) has been associated with a variety of human diseases, including Parkinson's disease and Crohn's disease, whereas <i>LRRK2</i> deficiency leads to accumulation of abnormal lysosomes in aged animals.
|
30209220 |
2018 |
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Genome-wide association studies have identified several genes implicated in autophagy (ATG16L1, IRGM, ULK1, LRRK2, and MTMR3), intracellular bacterial sensing (NOD2), and endoplasmic reticulum (ER) stress (XBP1 and ORMDL3) to be associated with Crohn disease (CD).
|
24247223 |
2013 |
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Leucine-rich repeat kinase 2 (LRRK2) is a large multidomain kinase/GTPase that has been recently linked to three pathological conditions: Parkinson's disease; Crohn's disease; and leprosy.
|
22594666 |
2012 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the gene encoding LRRK2 have been linked to multiple diseases, including a prominent association with familial and sporadic Parkinson's disease (PD), as well as inflammatory bowel disorders such as Crohn's disease.
|
23729298 |
2014 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Variants in the leucine-rich repeat kinase-2 (<i>LRRK2</i>) gene are associated with Parkinson's disease, leprosy, and Crohn's disease, three disorders with inflammation as an important component.
|
31554740 |
2019 |
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Furthermore, the risk-associated allele encoding LRRK2 Met2397 identified by a genome-wide association study for Crohn's disease resulted in less LRRK2 protein post-translationally.
|
21983832 |
2011 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We retrospectively investigated the co-occurrence of Crohn's disease in a cohort of 876 patients with Parkinson's disease, based on the observation that LRRK2 is a shared genetic risk factor.
|
28215729 |
2017 |
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
In this study, we found that LRRK2, encoded by a gene implicated in Crohn's disease, leprosy and familial Parkinson's disease, modulates the strength of Nod1/2-Rip2 signaling by enhancing Rip2 phosphorylation.
|
27830463 |
2017 |
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
While genome-wide association studies (GWAS) has linked LRRK2 with Crohn's disease and leprosy, it has received the greatest attention due to it being implicated as one of the genetic loci associated with autosomal dominant inheritance in Parkinson's disease (PD).
|
28117607 |
2017 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
CD susceptibility polymorphisms ATG16L1 rs2241880, ICAM1 rs5498, IL4 rs2070874, IL17F rs763780, IRGM rs13361189, ITLN1 rs2274910, LRRK2 rs11175593, and TLR4 rs4986790 were genotyped in a Portuguese population (511 CD patients, 626 controls) and assessed for association with CD clinical characteristics.
|
22573572 |
2013 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A pattern recognition receptor-type function for LRRK2 could explain its locus' association with Crohn's disease and leprosy risk.
|
21552986 |
2011 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We show that dendritic cells (DCs) from patients with Crohn's disease (CD) and lymphoblastoid cell lines derived from patients without CD but bearing a high-risk allele (rs11564258) at this locus as heterozygotes exhibited increased LRRK2 expression in vitro.
|
29875204 |
2018 |
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Leucine rich repeat kinase 2 is a complex enzyme with both kinase and GTPase activities, closely linked to the pathogenesis of several human disorders including Parkinson's disease, Crohn's disease, leprosy and cancer.
|
27731364 |
2016 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We specifically attempt to evaluate whether strong acting rare alleles, particularly protein-truncating or otherwise large effect-size alleles, enriched by the same founder-effect, contribute excess genetic risk to Crohn's disease in AJ, and find that ten rare genetic risk factors in NOD2 and LRRK2 are enriched in AJ (p < 0.005), including several novel contributing alleles, show evidence of association to CD.
|
29795570 |
2018 |
Parkinson Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
LRRK2 Parkinson's disease: from animal models to cellular mechanisms.
|
21679126 |
2011 |
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Variation contributing to the risk of Parkinson's disease (PD) has been identified in several genes and at several loci including GBA, SMPD1, LRRK2, POLG1, CHCHD10 and MAPT, but the frequencies of risk variants seem to vary according to ethnic background.
|
29029963 |
2017 |
Parkinson Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Interestingly, α-synuclein and LRRK2, key proteins involved in PD, function in different steps of the E-L pathway and target their components to induce disease pathogenesis.
|
31287913 |
2019 |