|
Demyelinating Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
These results suggest potential new avenues for the application of LRRK2 inhibitors in demyelinating diseases in which oligodendrocyte cell-death is one of the pathological features.
|
31825616 |
2020 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We provide evidence that LRRK2 was an independent prognostic factor for ICC in humans by participating in the proliferation and metastasis of ICC cells.
|
31489563 |
2020 |
|
Intrahepatic Cholangiocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The mechanism of LRRK2 in ICC development was also investigated in vitro.
|
31489563 |
2020 |
|
Primary cholangiocarcinoma of intrahepatic biliary tract
|
0.010 |
Biomarker
|
disease |
BEFREE |
LRRK2 Is Associated with Recurrence-Free Survival in Intrahepatic Cholangiocarcinoma and Downregulation of LRRK2 Suppresses Tumor Progress In Vitro.
|
31489563 |
2020 |
|
Behavioral and psychological symptoms of dementia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
The overall benefit of DBS in SNCA, GBA and LRRK2 p.T2031S mutations may be compromised due to rapid progression of cognitive and neuropsychiatric symptoms.
|
30659355 |
2020 |
|
Malignant tumor of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
The increased risks of leukemia as well as skin and colon cancers among LRRK2-PD patients suggest that LRRK2 mutations heighten risks of certain cancers.
|
31348549 |
2019 |
|
Malignant neoplasm of thyroid
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Downregulated LRRK2 gene expression inhibits proliferation and migration while promoting the apoptosis of thyroid cancer cells by inhibiting activation of the JNK signaling pathway.
|
31180559 |
2019 |
|
Cocaine Abuse
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This case report suggests that cocaine abuse indeed might be linked to secondary Parkinsonism and serves as an example of a potential gene-environmental interaction between the detected LRRK2 risk variant and cocaine abuse.
|
31660902 |
2019 |
|
Encephalitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mouse pups with reovirus-induced encephalitis that expressed the p.G2019S Lrrk2 mutation showed increased mortality despite lower viral titers.
|
31554740 |
2019 |
|
leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the pooled analysis, LRRK2-PD patients had also elevated risks of leukemia (OR = 9.84; 95% CI, 2.15-44.94) and colon cancer (OR = 2.34; 95% CI, 1.15-4.74) when compared with IPD patients.
|
31348549 |
2019 |
|
Lupus Nephritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Abbreviations: ALB: albumin; ARHGDIB: Rho GDP dissociation inhibitor beta; APOL1: apolipoprotein L1; ATG5: autophagy related 5; ATG7: autophagy related 7; ATG16L2: autophagy related 16 like 2; BECN1: beclin 1; CDKN1B: cyclin dependent kinase inhibitor 1B; CLEC16A, C-type lectin domain containing 16A; CYBB: cytochrome b-245 beta chain; DC: dendritic cell; DRAM1: DNA damage regulated autophagy modulator 1; eQTL: expression quantitative trait loci; GWAS: genome-wide association study; IFNA: interferon alpha; IRGM: immunity related GTPase M; LRRK2: leucine rich repeat kinase 2; MAP1LC3B: microtubule associated protein 1 light chain 3 beta; MTMR3: myotubularin related protein 3; LAP" LC3-associated phagocytosis; LN: lupus nephritis; NOD: non-obese diabetic; NPHS2: NPHS2, podocin; PBMC: peripheral blood mononuclear cell; RUBCN: rubicon autophagy regulator; SLE: systemic lupus erythematosus.
|
30755075 |
2019 |
|
Nephritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Negative correlations were observed between LRRK2 expression and serum C3 or C4 levels, two clinical features associated with SLE-related nephritis.
|
30670047 |
2019 |
|
nervous system disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
Notably, manganese (Mn) exposure leads to a PD-like neurological disorder referred to as manganism-and induces pathogenic PTMs of α-synuclein and LRRK2.
|
30481588 |
2019 |
|
Secondary Parkinson Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This case report suggests that cocaine abuse indeed might be linked to secondary Parkinsonism and serves as an example of a potential gene-environmental interaction between the detected LRRK2 risk variant and cocaine abuse.
|
31660902 |
2019 |
|
Psychotic Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
While GBA-PD is characterized by higher rates of dementia, probable RBD and psychosis, it seems that compared to the other groups, these features are less common for LRRK2-GBA-PD.
|
30573413 |
2019 |
|
Septicemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mice expressing Lrrk2 carrying the Parkinson's disease-linked p.G2019S mutation controlled infection better, with reduced bacterial growth and longer animal survival during sepsis.
|
31554740 |
2019 |
|
Thyroid Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Downregulated LRRK2 gene expression inhibits proliferation and migration while promoting the apoptosis of thyroid cancer cells by inhibiting activation of the JNK signaling pathway.
|
31180559 |
2019 |
|
Squamous cell carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, SNTG1 and LRRK2 might be important in LUAD and LUSC, respectively.
|
30549039 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, SNTG1 and LRRK2 might be important in LUAD and LUSC, respectively.
|
30549039 |
2019 |
|
Sepsis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mice expressing Lrrk2 carrying the Parkinson's disease-linked p.G2019S mutation controlled infection better, with reduced bacterial growth and longer animal survival during sepsis.
|
31554740 |
2019 |
|
Nonorganic psychosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
While GBA-PD is characterized by higher rates of dementia, probable RBD and psychosis, it seems that compared to the other groups, these features are less common for LRRK2-GBA-PD.
|
30573413 |
2019 |
|
Lupus Erythematosus
|
0.010 |
Biomarker
|
disease |
BEFREE |
LRRK2 is involved in the pathogenesis of system lupus erythematosus through promoting pathogenic antibody production.
|
30670047 |
2019 |
|
Colon Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the pooled analysis, LRRK2-PD patients had also elevated risks of leukemia (OR = 9.84; 95% CI, 2.15-44.94) and colon cancer (OR = 2.34; 95% CI, 1.15-4.74) when compared with IPD patients.
|
31348549 |
2019 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The biological functions of LINC01133, miR-205, and leucine-rich repeat kinase 2 (LRRK2) were validated on cell proliferation, migration, and invasion of ovarian cancer through gain-of-function and loss-of-function experiments.
|
31640854 |
2019 |
|
Childhood Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the pooled analysis, LRRK2-PD patients had also elevated risks of leukemia (OR = 9.84; 95% CI, 2.15-44.94) and colon cancer (OR = 2.34; 95% CI, 1.15-4.74) when compared with IPD patients.
|
31348549 |
2019 |