Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings delineate 5-HT as a critical determinant in BD associated maladaptive emotional responses and aberrant hippocampal neuroplasticity, and support the use of Tph2-/- mice as a new research tool for mechanistic and therapeutic research in bipolar disorder.
|
30087403 |
2018 |
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Eight eligible studies addressed association between 63 TPH2 gene single nucleotide polymorphisms (SNPs) with BD, after linkage disequilibrium analysis, 12 independent SNPs were identified.
|
26365518 |
2016 |
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results indicate that in the Han Chinese population TPH2 may be a potential susceptibility gene for bipolar disorder.
|
25152196 |
2015 |
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Our results indicate that in the Han Chinese population TPH2 may be a potential susceptibility gene for bipolar disorder.
|
25152196 |
2015 |
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the gene encoding the serotonin synthesis enzyme Tph2 have been identified in mental illnesses, including bipolar disorder, major depression, autism, schizophrenia, and ADHD.
|
24196946 |
2014 |
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Polymorphisms in the gene encoding the serotonin synthesis enzyme Tph2 have been identified in mental illnesses, including bipolar disorder, major depression, autism, schizophrenia, and ADHD.
|
24196946 |
2014 |
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
The aim of this study is to investigate a possible association between TPH2 gene polymorphisms and the PD comorbidity susceptibility.Our sample consisted of 515 patients; 274 patients with BD (subtypes I and II), including 45 patients with lifetime panic disorder comorbidity and 241 controls.
|
21085052 |
2011 |
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study is to investigate a possible association between TPH2 gene polymorphisms and the PD comorbidity susceptibility.Our sample consisted of 515 patients; 274 patients with BD (subtypes I and II), including 45 patients with lifetime panic disorder comorbidity and 241 controls.
|
21085052 |
2011 |
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Our results suggest that TPH2 variants neither have a major role in MD, BD and schizophrenia nor in response to treatments.
|
21396719 |
2011 |
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
We analyzed 62 genotyped variants within the selected genes (BDNF, NTRK2, SLC6A4, TPH2, P2RX7, DAOA, COMT, DISC1, and MAOA) against the presence of mood disorder, and in post-hoc analyses, specifically against bipolar disorder or major depressive disorder.
|
21438144 |
2011 |
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The present study is aimed at exploring whether some single nucleotide polymorphisms (SNPs) within the tryptophan hydroxylase 2 gene (TPH2) could be associated with major depression (MD), bipolar disorder (BD) and schizophrenia and whether they could predict clinical outcomes in Korean in-patients treated with antidepressants, mood stabilizers and antipsychotics, respectively.
|
21396719 |
2011 |
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our findings do not support the association between diagnosis of BD or suicidal behavior and TPH2 polymorphisms.
|
19800079 |
2010 |
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results strongly support a role for TPH2 in the aetiology of BPAD.
|
19352219 |
2009 |
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Examination of the functional effects of TPH2 Pro206Ser provided evidence for a reduced thermal stability and solubility of the mutated enzyme, suggesting reduced 5-HT production in the brain as a pathophysiological mechanism in BPAD.
|
17905754 |
2008 |
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Examination of the functional effects of TPH2 Pro206Ser provided evidence for a reduced thermal stability and solubility of the mutated enzyme, suggesting reduced 5-HT production in the brain as a pathophysiological mechanism in BPAD.
|
17905754 |
2008 |
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Case-control and family-based association studies further support the presence of a susceptibility locus for bipolar disorder in tryptophan hydroxylase 2 by showing statistically significant associations with both, single nucleotide polymorphism alone and haplotype of single nucleotide polymorphism markers.
|
17167340 |
2007 |
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Case-control and family-based association studies further support the presence of a susceptibility locus for bipolar disorder in tryptophan hydroxylase 2 by showing statistically significant associations with both, single nucleotide polymorphism alone and haplotype of single nucleotide polymorphism markers.
|
17167340 |
2007 |
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Despite reports of possible associations between polymorphisms in human TPH2 and many psychiatric disorders, including bipolar disorder (BPD), the functional effect and susceptibility loci of such polymorphisms for BPD have not yet been identified.
|
17768266 |
2007 |
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We tested for a relationship between genetic variation in TPH2 and risk for BPAD and SA in a large family sample.
|
16806105 |
2007 |
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Association of brain-specific tryptophan hydroxylase, TPH2, with unipolar and bipolar disorder in a Northern Swedish, isolated population.
|
17015812 |
2006 |
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
TPH2 genotypes were determined in 69 subjects with a diagnosis of schizophrenia or bipolar disorder, among which 22 died by suicide.
|
16436194 |
2006 |
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Further investigations of Tph2 are needed to clarify the potential role of this gene in the pathophysiology of bipolar disorder.
|
16240163 |
2005 |