Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Our findings provide evidence for an involvement of genetic variants of the TPH2 gene in the pathogenesis of MD and might be a hint on the repeatedly discussed duality of the serotonergic system.
|
15124006 |
2004 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression.
|
15629698 |
2005 |
Unipolar Depression
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Neuronal tryptophan hydroxylase mRNA expression in the human dorsal and median raphe nuclei: major depression and suicide.
|
16192985 |
2006 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
BEFREE |
Markers in TPH2 have been implicated in suicide and major depressive disorder, but the results across studies are inconsistent.
|
16806105 |
2007 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Effect of tryptophan hydroxylase-2 gene variants on suicide risk in major depression.
|
17217922 |
2007 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Genetic variations in the TPH2 gene have been associated with an increased risk for major depression and suicidal behavior.
|
17251907 |
2007 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
There was no association between TPH-2 gene variants and MD in the same population that had shown a strong association with TPH-1.
|
17692928 |
2008 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
CTD_human |
Up-regulation of tryptophan hydroxylase-2 mRNA in the rat brain by chronic fluoxetine treatment correlates with its antidepressant effect.
|
17950541 |
2007 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
This SNP and additional SNPs were discovered through a systematic characterization of the genetic architecture of the TPH2 gene for further genetic and functional investigations of its relationship to major depression and other psychopathology.
|
18180764 |
2008 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
MGD |
Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency.
|
18212115 |
2008 |
Unipolar Depression
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
The mechanisms underlying these changes are uncertain, but increased TPH2 expression and serotonin turnover could result from genetic influences, adverse early life experiences, or acute stressful life events, all of which can alter serotonergic neurotransmission and have been implicated in determining vulnerability to major depression.
|
19120094 |
2008 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, an increased frequency of G allele of TPH2 SNP may be associated with elevated suicidal behavior itself rather than with the diagnosis of major depression and may increase risk of suicidality, independent of diagnosis.
|
19162119 |
2009 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Although the sample size is small, results from this study suggest that the TPH2 C2755A polymorphism may represent a population-specific risk factor for peripartum major depression and anxiety disorder, perhaps by interacting with hormones.
|
19588223 |
2009 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression.
|
19590397 |
2009 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Those who did not drink alcohol before suicide were more likely to have a diagnosis of major depressive disorder in their medical record and more often had the TT genotype of the tryptophan hydroxylase 2 gene.
|
19734157 |
2010 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Effect of tryptophan hydroxylase-2 rs7305115 SNP on suicide attempts risk in major depression.
|
20738857 |
2010 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that TPH2 variants neither have a major role in MD, BD and schizophrenia nor in response to treatments.
|
21396719 |
2011 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
BEFREE |
Tryptophan hydroxylase 2 gene is associated with major depressive disorder in a female Chinese population.
|
21620479 |
2011 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
In total, 14 single nucleotide polymorphisms (SNPs) in coding regions of 10 serotonergic genes (HTR1A, HTR1B, HTR1D, HTR2A, HTR3A, HTR3C, HTR3D, HTR3E, HTR5A and TPH2) were genotyped in 308 Chinese Han patients with major depressive disorder.
|
21937687 |
2012 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
TPH2 gene polymorphisms and major depression--a meta-analysis.
|
22693556 |
2012 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
PSYGENET |
A rare mutation in tryptophan hydroxylase 2 (Tph2), the rate limiting enzyme for 5-HT synthesis, was identified in several patients with major depression, and knock-in mice expressing the analogous mutation (R439H Tph2 KI) show 80% reduction in 5-HT synthesis and tissue levels.
|
23336047 |
2013 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Although the majority of first-line antidepressants increase brain serotonin and rare polymorphisms in tryptophan hydroxlase-2 (Tph2), the rate-limiting enzyme in the brain serotonin synthesis pathway, have been identified in cohorts of subjects with major depressive disorder, the circuit level alterations that results from serotonergic hypofunction remain poorly understood.
|
23467366 |
2013 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
MGD |
Although the majority of first-line antidepressants increase brain serotonin and rare polymorphisms in tryptophan hydroxlase-2 (Tph2), the rate-limiting enzyme in the brain serotonin synthesis pathway, have been identified in cohorts of subjects with major depressive disorder, the circuit level alterations that results from serotonergic hypofunction remain poorly understood.
|
23467366 |
2013 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
PSYGENET |
Although the majority of first-line antidepressants increase brain serotonin and rare polymorphisms in tryptophan hydroxlase-2 (Tph2), the rate-limiting enzyme in the brain serotonin synthesis pathway, have been identified in cohorts of subjects with major depressive disorder, the circuit level alterations that results from serotonergic hypofunction remain poorly understood.
|
23467366 |
2013 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
PSYGENET |
Polymorphisms in the gene encoding the serotonin synthesis enzyme Tph2 have been identified in mental illnesses, including bipolar disorder, major depression, autism, schizophrenia, and ADHD.
|
24196946 |
2014 |