Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression.
|
19590397 |
2009 |
Unipolar Depression
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Neuronal tryptophan hydroxylase mRNA expression in the human dorsal and median raphe nuclei: major depression and suicide.
|
16192985 |
2006 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
BEFREE |
Tryptophan hydroxylase 2 gene is associated with major depressive disorder in a female Chinese population.
|
21620479 |
2011 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
TPH2 gene polymorphisms and major depression--a meta-analysis.
|
22693556 |
2012 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
TPH2 rs4290270 was genotyped in 165 suicide attempters and 188 suicide non-attempters diagnosed with major depressive disorder, bipolar disorder and schizophrenia.
|
28084537 |
2017 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
TPH-2 Gene Polymorphism in Major Depressive Disorder Patients With Early-Wakening Symptom.
|
30519155 |
2018 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Tryptophan hydroxylase-2 polymorphism is associated with white matter integrity in first-episode, medication-naïve major depressive disorder patients.
|
30822678 |
2019 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
PSYGENET |
A rare mutation in tryptophan hydroxylase 2 (Tph2), the rate limiting enzyme for 5-HT synthesis, was identified in several patients with major depression, and knock-in mice expressing the analogous mutation (R439H Tph2 KI) show 80% reduction in 5-HT synthesis and tissue levels.
|
23336047 |
2013 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Although the majority of first-line antidepressants increase brain serotonin and rare polymorphisms in tryptophan hydroxlase-2 (Tph2), the rate-limiting enzyme in the brain serotonin synthesis pathway, have been identified in cohorts of subjects with major depressive disorder, the circuit level alterations that results from serotonergic hypofunction remain poorly understood.
|
23467366 |
2013 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
MGD |
Although the majority of first-line antidepressants increase brain serotonin and rare polymorphisms in tryptophan hydroxlase-2 (Tph2), the rate-limiting enzyme in the brain serotonin synthesis pathway, have been identified in cohorts of subjects with major depressive disorder, the circuit level alterations that results from serotonergic hypofunction remain poorly understood.
|
23467366 |
2013 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
PSYGENET |
Although the majority of first-line antidepressants increase brain serotonin and rare polymorphisms in tryptophan hydroxlase-2 (Tph2), the rate-limiting enzyme in the brain serotonin synthesis pathway, have been identified in cohorts of subjects with major depressive disorder, the circuit level alterations that results from serotonergic hypofunction remain poorly understood.
|
23467366 |
2013 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Although the sample size is small, results from this study suggest that the TPH2 C2755A polymorphism may represent a population-specific risk factor for peripartum major depression and anxiety disorder, perhaps by interacting with hormones.
|
19588223 |
2009 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Effect of tryptophan hydroxylase-2 gene variants on suicide risk in major depression.
|
17217922 |
2007 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Effect of tryptophan hydroxylase-2 rs7305115 SNP on suicide attempts risk in major depression.
|
20738857 |
2010 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, an increased frequency of G allele of TPH2 SNP may be associated with elevated suicidal behavior itself rather than with the diagnosis of major depression and may increase risk of suicidality, independent of diagnosis.
|
19162119 |
2009 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Genetic variations in the TPH2 gene have been associated with an increased risk for major depression and suicidal behavior.
|
17251907 |
2007 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
In total, 14 single nucleotide polymorphisms (SNPs) in coding regions of 10 serotonergic genes (HTR1A, HTR1B, HTR1D, HTR2A, HTR3A, HTR3C, HTR3D, HTR3E, HTR5A and TPH2) were genotyped in 308 Chinese Han patients with major depressive disorder.
|
21937687 |
2012 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Lack of association between TPH2 gene polymorphisms with major depressive disorder in multiethnic Malaysian population.
|
24376086 |
2015 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
PSYGENET |
Lack of association between TPH2 gene polymorphisms with major depressive disorder in multiethnic Malaysian population.
|
24376086 |
2015 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Local gyrification index in patients with major depressive disorder and its association with tryptophan hydroxylase-2 (TPH2) polymorphism.
|
27807918 |
2017 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression.
|
15629698 |
2005 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
BEFREE |
Markers in TPH2 have been implicated in suicide and major depressive disorder, but the results across studies are inconsistent.
|
16806105 |
2007 |
Unipolar Depression
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Methylation of the tryptophan hydroxylase‑2 gene is associated with mRNA expression in patients with major depression with suicide attempts.
|
25955598 |
2015 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Our findings provide evidence for an involvement of genetic variants of the TPH2 gene in the pathogenesis of MD and might be a hint on the repeatedly discussed duality of the serotonergic system.
|
15124006 |
2004 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that TPH2 variants neither have a major role in MD, BD and schizophrenia nor in response to treatments.
|
21396719 |
2011 |