TPH2, tryptophan hydroxylase 2, 121278

N. diseases: 137; N. variants: 37
Disease: Major Depressive Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 Biomarker disease BEFREE In this study, we aimed to investigate the association of tryptophan hydroxylase 2 gene with MDD and its treatment response in the Chinese Han population. 21620479 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 Biomarker disease CTD_human
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 Biomarker disease PSYGENET Polymorphisms in the gene encoding the serotonin synthesis enzyme Tph2 have been identified in mental illnesses, including bipolar disorder, major depression, autism, schizophrenia, and ADHD. 24196946 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 Biomarker disease PSYGENET Single locus analysis in pooled and ethnically stratified subjects revealed no association between each of the three variants of the TPH2 gene with susceptibility to MDD. 24376086 2015
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 Biomarker disease BEFREE We conducted a 12-week randomized-controlled trial comparing the effects of EPA and DHA on gene expressions of phospholipase A2 (cPLA2) and cyclooxygenase-2 (COX2), serotonin transporter (5HTT), and Tryptophan hydroxylase 2 (TPH-2) in 27 MDD patients. 28648567 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 Biomarker disease BEFREE Gene-disease association studies have reported a relationship between TPH2 and major depressive disorder (MDD) in different populations, however subsequent studies have produced contradictory results. 22693556 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 Biomarker disease BEFREE The study suggested that hopelessness, negative life events and family history of suicide were risk factors of attempted suicide in MDD while the TPH2 rs7305115A remained a significant protective predictor of suicide attempts. 20738857 2010
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 Biomarker disease BEFREE The Interaction of TPH2 and 5-HT2A Polymorphisms on Major Depressive Disorder Susceptibility in a Chinese Han Population: A Case-Control Study. 31019472 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 Biomarker disease PSYGENET Although the majority of first-line antidepressants increase brain serotonin and rare polymorphisms in tryptophan hydroxlase-2 (Tph2), the rate-limiting enzyme in the brain serotonin synthesis pathway, have been identified in cohorts of subjects with major depressive disorder, the circuit level alterations that results from serotonergic hypofunction remain poorly understood. 23467366 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 PosttranslationalModification disease BEFREE In conclusion, the present study demonstrated that TPH2 expression was regulated by DNA methylation of the TPH2 promoter region in patients with MDD. 25955598 2015
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 AlteredExpression disease BEFREE The mechanisms underlying these changes are uncertain, but increased TPH2 expression and serotonin turnover could result from genetic influences, adverse early life experiences, or acute stressful life events, all of which can alter serotonergic neurotransmission and have been implicated in determining vulnerability to major depression. 19120094 2008
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 AlteredExpression disease BEFREE Neuronal tryptophan hydroxylase mRNA expression in the human dorsal and median raphe nuclei: major depression and suicide. 16192985 2006