Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Cloning and sequencing of the monocarboxylate transporter from mouse Ehrlich Lettré tumour cell confirms its identity as MCT1 and demonstrates that glycosylation is not required for MCT1 function.
|
8603082 |
1996 |
Hypertrophic Cardiomyopathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Angiotensin-converting enzyme and heart chymase gene polymorphisms in hypertrophic cardiomyopathy.
|
8759823 |
1996 |
Hypertrophic obstructive cardiomyopathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Angiotensin-converting enzyme and heart chymase gene polymorphisms in hypertrophic cardiomyopathy.
|
8759823 |
1996 |
Eczema
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Association between variants of mast cell chymase gene and serum IgE levels in eczema.
|
9463800 |
1998 |
Cardiomyopathies
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In the present study we determined the gene organization of a novel hamster chymase (hamster chymase 2) and analysed the expression of chymase 1, chymase 2 and angiotensin-converting enzyme (ACE) in hamster hearts at the terminal stage of cardiomyopathy.
|
9657983 |
1998 |
Eczema
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
No evidence for an association between a variant of the mast cell chymase gene and atopic dermatitis based on case-control and haplotype-relative-risk analyses.
|
9748697 |
1998 |
Dermatitis, Atopic
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
No evidence for an association between a variant of the mast cell chymase gene and atopic dermatitis based on case-control and haplotype-relative-risk analyses.
|
9748697 |
1998 |
Myocardial Infarction
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Chymase gene locus is not associated with myocardial infarction and is not linked to heart size or blood pressure.
|
9794357 |
1998 |
Heart Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The chymase gene is said to be important for the generation of angiotensin II in the heart and therefore is a candidate gene for heart disease.
|
9794357 |
1998 |
Acute myocardial infarction
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
However, we were unable to find an association between allelic variants of the chymase gene and acute myocardial infarction or linkage between the chymase gene locus and heart size.
|
9794357 |
1998 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Angiotensinogen M235T and chymase gene CMA/B polymorphisms are not associated with nephropathy in type II diabetes.
|
11096141 |
2000 |
Kidney Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Our study provided evidence against an association between angiotensinogen M235T or chymase gene CMA/B polymorphisms and the presence of incipient or overt nephropathy in Caucasian patients with type II diabetes.
|
11096141 |
2000 |
Eczema
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Absence of association between a variant of the mast cell chymase gene and atopic dermatitis in an Italian population.
|
11173969 |
2001 |
Dermatitis, Atopic
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Absence of association between a variant of the mast cell chymase gene and atopic dermatitis in an Italian population.
|
11173969 |
2001 |
Arteriosclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A chymase gene variant is associated with atherosclerosis in venous coronary artery bypass grafts.
|
11696688 |
2001 |
Atherosclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A chymase gene variant is associated with atherosclerosis in venous coronary artery bypass grafts.
|
11696688 |
2001 |
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Carcinoma samples displaying reduced levels of MCT1 were found to express the high affinity glucose transporter, GLUT1, suggesting that there is a switch from butyrate to glucose as an energy source in colonic epithelia during transition to malignancy.
|
11953883 |
2002 |
Primary malignant neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Carcinoma samples displaying reduced levels of MCT1 were found to express the high affinity glucose transporter, GLUT1, suggesting that there is a switch from butyrate to glucose as an energy source in colonic epithelia during transition to malignancy.
|
11953883 |
2002 |
Carcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Analysis of healthy colonic tissues and carcinomas using immunohistochemistry and Western blotting revealed a significant decline in the expression of MCT1 protein during transition from normality to malignancy.
|
11953883 |
2002 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
GeneticVariation
|
disease |
LHGDN |
Angiotensin I-converting enzyme and chymase gene polymorphisms - relationship to left ventricular mass in type 2 diabetes patients.
|
12165749 |
2002 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Angiotensin I-converting enzyme and chymase gene polymorphisms - relationship to left ventricular mass in type 2 diabetes patients.
|
12165749 |
2002 |
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We examined a diverse panel of lymphoid malignancies for the expression of MCT-1.
|
12637315 |
2003 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our data suggest that high levels of MCT-1 protein may be associated with a high-risk subset of lymphoid neoplasms and may further support the potential role of MCT-1 in promoting human lymphoid tumor development.
|
12637315 |
2003 |
Diffuse Large B-Cell Lymphoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we identified a subset of primary diffuse large B-cell lymphomas that exhibited elevated levels of MCT-1 protein.
|
12637315 |
2003 |
T-Cell Lymphoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Our laboratory has recently discovered a novel candidate oncogene, MCT-1, amplified in human T-cell lymphoma and mapped to chromosome Xq22-24.
|
12637315 |
2003 |